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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-7
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pubmed:abstractText |
Lysophosphatidic acid (LPA) is a potent inducer of colon cancer and LPA receptor type 2 (LPA(2)) is overexpressed in colon tumors. LPA(2) interacts with membrane-associated guanylate kinase with inverted orientation-3 (MAGI-3) and the Na+/H+ exchanger regulatory factor 2 (NHERF-2), but the biological effects of these interactions are unknown. We investigated the roles of MAGI-3 and NHERF-2 in LPA(2)-mediated signaling in human colon cancer cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/MAGI3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/PLCB3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipase C beta,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lysophosphatidic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Hydrogen Antiporter,
http://linkedlifedata.com/resource/pubmed/chemical/lysophosphatidic acid,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-hydrogen exchanger...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
924-34
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pubmed:meshHeading |
pubmed-meshheading:21134377-Adenocarcinoma,
pubmed-meshheading:21134377-Adenomatous Polyposis Coli,
pubmed-meshheading:21134377-Animals,
pubmed-meshheading:21134377-Cell Movement,
pubmed-meshheading:21134377-Colonic Neoplasms,
pubmed-meshheading:21134377-Disease Models, Animal,
pubmed-meshheading:21134377-GTP-Binding Protein alpha Subunits, G12-G13,
pubmed-meshheading:21134377-GTP-Binding Protein alpha Subunits, Gq-G11,
pubmed-meshheading:21134377-Genes, APC,
pubmed-meshheading:21134377-HCT116 Cells,
pubmed-meshheading:21134377-Humans,
pubmed-meshheading:21134377-Inositol Phosphates,
pubmed-meshheading:21134377-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:21134377-Lysophospholipids,
pubmed-meshheading:21134377-Membrane Proteins,
pubmed-meshheading:21134377-Mice,
pubmed-meshheading:21134377-NF-kappa B,
pubmed-meshheading:21134377-Neoplasm Invasiveness,
pubmed-meshheading:21134377-Phospholipase C beta,
pubmed-meshheading:21134377-Phosphoproteins,
pubmed-meshheading:21134377-RNA Interference,
pubmed-meshheading:21134377-Receptors, Lysophosphatidic Acid,
pubmed-meshheading:21134377-Signal Transduction,
pubmed-meshheading:21134377-Sodium-Hydrogen Antiporter,
pubmed-meshheading:21134377-Time Factors,
pubmed-meshheading:21134377-Tissue Array Analysis,
pubmed-meshheading:21134377-Transfection
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pubmed:year |
2011
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pubmed:articleTitle |
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
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pubmed:affiliation |
Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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