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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1990-7-24
|
| pubmed:abstractText |
In an attempt to determine the rate of transmission of infection from human immunodeficiency virus type 1 (HIV-1) antibody-positive women to their offspring and to describe the short-term outcome of perinatal infection, we enrolled 62 infants in a prospective cohort study during a 30-month period and followed them up for an additional 6 months. The clinical, immunologic, and serologic status of the children was assessed prospectively. Fourteen subjects were symptomatic: 3 had acquired immunodeficiency syndrome, 5 had signs and symptoms that were compatible with HIV-1 infection (Centers for Disease Control, Atlanta, Ga, class P2A), and 6 had ill-defined symptoms that could not be definitely attributed to HIV. Our data indicated that the maximum rate of vertical transmission of HIV-1 infection in New Haven, Conn, was less than 30%, and the rate of HIV-1-associated disease occurring during the first 3 years of life was 16%. The mean and median time to loss of maternal antibody, as detected by Western blot in seroreverters, was approximately 7 months, and the half-life of passive antibody was 38 days. A continued close follow-up of children in the cohort studied, and others like it, is critical to learn the full range of outcomes of HIV infection in the pediatric population.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0002-922X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
144
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
758-66
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2113349-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2113349-Child, Preschool,
pubmed-meshheading:2113349-Female,
pubmed-meshheading:2113349-Follow-Up Studies,
pubmed-meshheading:2113349-Gene Products, gag,
pubmed-meshheading:2113349-HIV Antigens,
pubmed-meshheading:2113349-HIV Core Protein p24,
pubmed-meshheading:2113349-HIV-1,
pubmed-meshheading:2113349-Half-Life,
pubmed-meshheading:2113349-Humans,
pubmed-meshheading:2113349-Immunity, Maternally-Acquired,
pubmed-meshheading:2113349-Infant,
pubmed-meshheading:2113349-Infant, Newborn,
pubmed-meshheading:2113349-Male,
pubmed-meshheading:2113349-Pregnancy,
pubmed-meshheading:2113349-Pregnancy Complications, Infectious,
pubmed-meshheading:2113349-Prognosis,
pubmed-meshheading:2113349-Viral Core Proteins
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Rate of transmission of human immunodeficiency virus type 1 infection from mother to child and short-term outcome of neonatal infection. Results of a prospective cohort study.
|
| pubmed:affiliation |
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|