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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1990-7-26
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pubmed:abstractText |
The effect of perfluorochemicals in combination with carbogen breathing on the response of SCK tumors of mice to fractionated irradiation was investigated. The SCK tumors of A/J mice were irradiated twice a day at 3 Gy per fraction (6 Gy per day), with a total dose of 18 Gy over 3 days. When the host animals were treated with an intravenous (iv) injection of 12 ml/kg of Fluosol-DA 20% before the first daily tumor irradiation and carbogen breathing during every X irradiation with Fluosol-DA 20% injection without carbogen breathing. The hypoxic cell fraction, as determined by an in vivo-in vitro cloning assay, decreased significantly, and the intratumor pO2, as determined with microelectrodes, was markedly increased by Fluosol-DA 20% injection and carbogen breathing. It was concluded that oxygenation of hypoxic cells in SCK tumors during the course of fractionated irradiation was improved by the iv injection of Fluosol-DA 20% and carbogen breathing.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0033-7587
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2113298-Adenocarcinoma,
pubmed-meshheading:2113298-Administration, Inhalation,
pubmed-meshheading:2113298-Animals,
pubmed-meshheading:2113298-Carbon Dioxide,
pubmed-meshheading:2113298-Drug Combinations,
pubmed-meshheading:2113298-Drug Therapy, Combination,
pubmed-meshheading:2113298-Fluorocarbons,
pubmed-meshheading:2113298-Injections, Intravenous,
pubmed-meshheading:2113298-Mammary Neoplasms, Experimental,
pubmed-meshheading:2113298-Mice,
pubmed-meshheading:2113298-Neoplasm Transplantation,
pubmed-meshheading:2113298-Oxygen,
pubmed-meshheading:2113298-Radiation-Sensitizing Agents
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pubmed:year |
1990
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pubmed:articleTitle |
Radiosensitization of murine tumors by Fluosol-DA 20%.
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pubmed:affiliation |
University of Minnesota Medical School, Department of Therapeutic Radiology, Minneapolis 55455.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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