|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2010-12-28
|
|
pubmed:abstractText |
The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We generated a comprehensive transcriptional profile of the separate stages of spontaneous remyelination that follow focal demyelination in the rat CNS and found that transcripts that encode the retinoid acid receptor RXR-? were differentially expressed during remyelination. Cells of the oligodendrocyte lineage expressed RXR-? in rat tissues that were undergoing remyelination and in active and remyelinated multiple sclerosis lesions. Knockdown of RXR-? by RNA interference or RXR-specific antagonists severely inhibited oligodendrocyte differentiation in culture. In mice that lacked RXR-?, adult oligodendrocyte precursor cells efficiently repopulated lesions after demyelination, but showed delayed differentiation into mature oligodendrocytes. Administration of the RXR agonist 9-cis-retinoic acid to demyelinated cerebellar slice cultures and to aged rats after demyelination caused an increase in remyelinated axons. Our results indicate that RXR-? is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination and might be a pharmacological target for regenerative therapy in the CNS.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1546-1726
|
|
pubmed:author |
pubmed-author:BauerJulienJ,
pubmed-author:ChambonPierreP,
pubmed-author:EvercoorenAnne Baron-VanAB,
pubmed-author:Ffrench-ConstantCharlesC,
pubmed-author:FranklinRobin J MRJ,
pubmed-author:HuangJeffrey KJK,
pubmed-author:JarjourAndrew AAA,
pubmed-author:KagechikaHiroyukiH,
pubmed-author:KerninonChristopheC,
pubmed-author:KrezelWojciechW,
pubmed-author:Nait OumesmarBrahimB,
pubmed-author:WilliamsAnnaA,
pubmed-author:ZhaoChaoC
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
45-53
|
|
pubmed:dateRevised |
2011-2-9
|
|
pubmed:meshHeading |
pubmed-meshheading:21131950-Aged,
pubmed-meshheading:21131950-Animals,
pubmed-meshheading:21131950-Benzoic Acids,
pubmed-meshheading:21131950-Biphenyl Compounds,
pubmed-meshheading:21131950-Cell Differentiation,
pubmed-meshheading:21131950-Cell Lineage,
pubmed-meshheading:21131950-Cells, Cultured,
pubmed-meshheading:21131950-Central Nervous System,
pubmed-meshheading:21131950-Cerebellum,
pubmed-meshheading:21131950-Demyelinating Diseases,
pubmed-meshheading:21131950-Female,
pubmed-meshheading:21131950-Gene Expression Profiling,
pubmed-meshheading:21131950-Humans,
pubmed-meshheading:21131950-Male,
pubmed-meshheading:21131950-Mice,
pubmed-meshheading:21131950-Mice, Knockout,
pubmed-meshheading:21131950-Middle Aged,
pubmed-meshheading:21131950-Multiple Sclerosis,
pubmed-meshheading:21131950-Myelin Sheath,
pubmed-meshheading:21131950-Nerve Regeneration,
pubmed-meshheading:21131950-Neurotoxins,
pubmed-meshheading:21131950-Oligodendroglia,
pubmed-meshheading:21131950-RNA Interference,
pubmed-meshheading:21131950-Rats,
pubmed-meshheading:21131950-Rats, Sprague-Dawley,
pubmed-meshheading:21131950-Receptors, Retinoic Acid,
pubmed-meshheading:21131950-Stem Cells,
pubmed-meshheading:21131950-Tretinoin
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Retinoid X receptor gamma signaling accelerates CNS remyelination.
|
|
pubmed:affiliation |
MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
