21131556

Source:http://linkedlifedata.com/resource/pubmed/id/21131556

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002842, umls-concept:C0030705, umls-concept:C0205314, umls-concept:C0205390, umls-concept:C0376358, umls-concept:C0679622, umls-concept:C1831892, umls-concept:C2603343
pubmed:issue	4
pubmed:dateCreated	2011-2-17
pubmed:abstractText	BMS-641988 is an androgen receptor antagonist with increased potency relative to bicalutamide in both in vitro and in vivo prostate cancer models. A first-in-man phase I study was conducted to define the safety and tolerability of oral BMS-641988 in patients with castration-resistant prostate cancer (CRPC).
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/5P30CA006973, http://linkedlifedata.com/resource/pubmed/grant/P30 CA006973-48
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-10550143, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-10655437, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-11325816, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-14755679, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-16278481, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-18309951, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-19359544, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-19470933, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-19654297, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-20398925, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-20579941, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-9092797, http://linkedlifedata.com/resource/pubmed/commentcorrection/21131556-9126240
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Androgen Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/BMS 641988, http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic, http://linkedlifedata.com/resource/pubmed/chemical/Imides, http://linkedlifedata.com/resource/pubmed/chemical/Prostate-Specific Antigen
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1078-0432
pubmed:author	pubmed-author:AllandLeilaL, pubmed-author:AnandAseemA, pubmed-author:CarducciMichael AMA, pubmed-author:ChengShintaS, pubmed-author:EisenbergerMario AMA, pubmed-author:FungNga Kit ElizaNK, pubmed-author:GanJinpingJ, pubmed-author:GottardisMarcoM, pubmed-author:LiuGlennG, pubmed-author:MorrisMichael JMJ, pubmed-author:ObermeierMary TMT, pubmed-author:OzonoSeiichiroS, pubmed-author:Prostate Cancer Clinical Trials Consortium, pubmed-author:RathkopfDanaD, pubmed-author:ReddyJyotsnaJ, pubmed-author:SasakiYasutsunaY, pubmed-author:ScherHoward IHI, pubmed-author:SlovinSusan FSF, pubmed-author:TakahashiShunjiS, pubmed-author:VakkalagaddaBlisse JBJ, pubmed-author:WildingGeorgeG, pubmed-author:ZhangStevenS
pubmed:copyrightInfo	©2010 AACR.
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	880-7
pubmed:meshHeading	pubmed-meshheading:21131556-Aged, pubmed-meshheading:21131556-Aged, 80 and over, pubmed-meshheading:21131556-Androgen Antagonists, pubmed-meshheading:21131556-Bicyclo Compounds, Heterocyclic, pubmed-meshheading:21131556-Bone Neoplasms, pubmed-meshheading:21131556-Humans, pubmed-meshheading:21131556-Imides, pubmed-meshheading:21131556-Male, pubmed-meshheading:21131556-Middle Aged, pubmed-meshheading:21131556-Orchiectomy, pubmed-meshheading:21131556-Prostate-Specific Antigen, pubmed-meshheading:21131556-Prostatic Neoplasms, pubmed-meshheading:21131556-Treatment Outcome
pubmed:year	2011
pubmed:articleTitle	Phase I dose-escalation study of the novel antiandrogen BMS-641988 in patients with castration-resistant prostate cancer.
pubmed:affiliation	Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
pubmed:publicationType	Journal Article, Randomized Controlled Trial, Multicenter Study, Clinical Trial, Phase I, Research Support, N.I.H., Extramural