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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-27
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pubmed:abstractText |
This study explores the role of procalcitonin (PCT) in predicting the outcome of sepsis. In a prospective multicentre observational investigation, blood was sampled within 24 h of onset of sepsis in 1156 hospitalised patients; 234 were in the intensive care unit (ICU) at the point of presentation of sepsis while 922 were not. PCT was estimated in serum by the ultrasensitive Kryptor assay in a double-blinded fashion. Among patients outside the ICU, mortality was 8% in those with PCT ?0.12 ng/mL but 19.9% in those with PCT >0.12 ng/mL [P<0.0001, odds ratio (OR) for death: 2.606; 95% confidence interval (CI): 1.553-4.371]. Among patients whose sepsis presented in ICU, mortality was 25.6% in those with PCT ?0.85 ng/mL but 45.3% in those with PCT >0.85 ng/mL (P=0.002; OR for death: 2.404; 95% CI: 1.385-4.171). It is concluded that PCT cut-off concentrations can contribute to predicting the outcome of sepsis and might be of particular value in identifying patients who would benefit from ICU admission.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1532-2939
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pubmed:author |
pubmed-author:AdamisGG,
pubmed-author:ArmaganidisAA,
pubmed-author:AtmatzidisSS,
pubmed-author:ChrisofosMM,
pubmed-author:DouzinasE EEE,
pubmed-author:EvangelopoulouVV,
pubmed-author:FrantzeskakiFF,
pubmed-author:GialvalisDD,
pubmed-author:Giamarellos-BourboulisE JEJ,
pubmed-author:GiannikopoulosGG,
pubmed-author:GiannopoulosPP,
pubmed-author:GogosCC,
pubmed-author:GourgoulisG MGM,
pubmed-author:Hellenic Sepsis Study Group,
pubmed-author:KanniThT,
pubmed-author:KatsifaKK,
pubmed-author:KofinasGG,
pubmed-author:KontopidouFF,
pubmed-author:KoratzanisGG,
pubmed-author:KotzampassiKK,
pubmed-author:KoulourasVV,
pubmed-author:KoupetoriMM,
pubmed-author:KoutsikouAA,
pubmed-author:KritselisII,
pubmed-author:LeonidouLL,
pubmed-author:MegeEE,
pubmed-author:MouktaroudiMM,
pubmed-author:MylonaVV,
pubmed-author:NikolaouHH,
pubmed-author:OrfanosSS,
pubmed-author:PanagopoulosPP,
pubmed-author:PantelidouII,
pubmed-author:PapadopoulosAA,
pubmed-author:PapanikolaouXX,
pubmed-author:ParamythiotouEE,
pubmed-author:PavlakiMM,
pubmed-author:PolychronopoulosVV,
pubmed-author:SkoutelisAA,
pubmed-author:TheodotouAA,
pubmed-author:TsangarisII,
pubmed-author:VassiliaghouMM
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pubmed:copyrightInfo |
Copyright © 2010 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
58-63
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pubmed:meshHeading |
pubmed-meshheading:21131099-Adult,
pubmed-meshheading:21131099-Aged,
pubmed-meshheading:21131099-Aged, 80 and over,
pubmed-meshheading:21131099-Calcitonin,
pubmed-meshheading:21131099-Clinical Laboratory Techniques,
pubmed-meshheading:21131099-Female,
pubmed-meshheading:21131099-Humans,
pubmed-meshheading:21131099-Male,
pubmed-meshheading:21131099-Middle Aged,
pubmed-meshheading:21131099-Prognosis,
pubmed-meshheading:21131099-Prospective Studies,
pubmed-meshheading:21131099-Protein Precursors,
pubmed-meshheading:21131099-Sepsis,
pubmed-meshheading:21131099-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
Procalcitonin as an early indicator of outcome in sepsis: a prospective observational study.
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pubmed:affiliation |
4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece. giamarel@ath.forthnet.gr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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