Linked Life Data

21130912

Source:http://linkedlifedata.com/resource/pubmed/id/21130912

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-12-6
pubmed:abstractText
Diabetes mellitus is a rapidly evolving area of medicine with the publication of new studies, the introduction of new drugs and a proliferation of clinical practice guidelines, often with subtle differences in the recommended therapeutic approach to patients with this disease. Notable among the extensive information generated on the disease in the last few years is evaluation of the studies with greatest impact on clinical practice in terms of defining glycemic targets and the preferred therapeutic strategy to achieve them. After the disappointing results of intensive glucose control in most patients revealed in the ACCORD, ADVANCE and VADT trials, recent data from the extensions of the UKPDS and STENO-2 trials have shown a new emphasis in the treatment of the disease, highlighting the importance of treatment and optimal glycemic control in the early stages. This strategy confers a long-term benefit on morbidity and mortality through a new concept which has become known as "metabolic memory" or the "legacy effect". Recently introduced drugs with action on the incretin system have been shown to have pleiotropic effects beyond their already confirmed effect on glycemic control, which could lead to their use becoming prioritized in the future. In view of these contributions, both through clinical trials and through data obtained with the new therapies, the overall management of diabetes should be modified. This need for modification is reflected in some of the most recent updates of clinical practice guidelines that incorporate some of these advances.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1578-1860
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier España S.L. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
210 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-25
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
[What has changed in the therapeutic strategy for type 2 diabetes mellitus?].
pubmed:affiliation
Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, España.
pubmed:publicationType
Journal Article, English Abstract