Linked Life Data

21130611

Source:http://linkedlifedata.com/resource/pubmed/id/21130611

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-24
pubmed:abstractText
Working memory (WM) is fractionated into systems for visuospatial and phonological information. Recently, it has been shown that the dopamine d2 receptor gene DRD2 and CHRNA4, the gene coding for the nicotinic acetylcholine receptor's alpha4 subunit, interact epistatically on visuospatial WM capacity. In the present study, we show a similar interaction on phonological WM capacity in N=137 healthy subjects genotyped for two single nucleotide polymorphisms (DRD2 rs6277 and CHRNA4 rs1044396). Given the functional independence of the two systems we hypothesize that the genetic interaction targets the central executive which is the common control process for both systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1873-7862
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. and ECNP. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216-20
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Evidence for the modality independence of the genetic epistasis between the dopaminergic and cholinergic system on working memory capacity.
pubmed:affiliation
Department of Psychology, University of Bonn, Laboratory of Neurogenetics, University of Bonn, Kaiser-Karl-Ring 9, Bonn, Germany. sebastian.markett@uni-bonn-diff.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't