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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-12-3
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pubmed:abstractText |
B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1740-2530
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2010
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
683875
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21127709-Antigens, CD,
pubmed-meshheading:21127709-B7 Antigens,
pubmed-meshheading:21127709-Cytokines,
pubmed-meshheading:21127709-Female,
pubmed-meshheading:21127709-Humans,
pubmed-meshheading:21127709-Immunomodulation,
pubmed-meshheading:21127709-Lymphocyte Activation,
pubmed-meshheading:21127709-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:21127709-Male,
pubmed-meshheading:21127709-Neoplasms,
pubmed-meshheading:21127709-Receptors, Immunologic,
pubmed-meshheading:21127709-Survival Analysis,
pubmed-meshheading:21127709-T-Lymphocytes,
pubmed-meshheading:21127709-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
B7-h3 and its role in antitumor immunity.
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pubmed:affiliation |
Chirurgische Klinik und Poliklinik, Klinikum Rechts der Isar, Technische Universität München, Germany.
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pubmed:publicationType |
Journal Article,
Review
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