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rdf:type |
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lifeskim:mentions |
umls-concept:C0006110,
umls-concept:C0009506,
umls-concept:C0013018,
umls-concept:C0022646,
umls-concept:C0040732,
umls-concept:C0205263,
umls-concept:C0205276,
umls-concept:C0332281,
umls-concept:C0392756,
umls-concept:C0450127,
umls-concept:C0542341
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pubmed:issue |
7
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pubmed:dateCreated |
2011-6-28
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pubmed:abstractText |
Kidneys derived from brain-dead donors have inferior outcomes after transplantation compared to kidneys from living donors. Strikingly, early and profound serum levels of IL-6 in brain-dead donors are observed. IL-6 is the main regulator of the acute phase response (APR). The aim of this translational study was to investigate the expression of renal acute phase proteins (APPs) following brain death (BD) and to assess the association with renal allograft outcome after transplantation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1460-2385
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2345-54
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pubmed:meshHeading |
pubmed-meshheading:21127132-Adult,
pubmed-meshheading:21127132-Animals,
pubmed-meshheading:21127132-Blotting, Western,
pubmed-meshheading:21127132-Brain Death,
pubmed-meshheading:21127132-Cold Ischemia,
pubmed-meshheading:21127132-Complement Activation,
pubmed-meshheading:21127132-Complement C3,
pubmed-meshheading:21127132-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21127132-Female,
pubmed-meshheading:21127132-Glomerular Filtration Rate,
pubmed-meshheading:21127132-Humans,
pubmed-meshheading:21127132-Immunoenzyme Techniques,
pubmed-meshheading:21127132-Interleukin-6,
pubmed-meshheading:21127132-Kidney Failure, Chronic,
pubmed-meshheading:21127132-Kidney Function Tests,
pubmed-meshheading:21127132-Kidney Transplantation,
pubmed-meshheading:21127132-Kidney Tubules,
pubmed-meshheading:21127132-Living Donors,
pubmed-meshheading:21127132-Male,
pubmed-meshheading:21127132-Middle Aged,
pubmed-meshheading:21127132-Prognosis,
pubmed-meshheading:21127132-RNA, Messenger,
pubmed-meshheading:21127132-Rats,
pubmed-meshheading:21127132-Rats, Inbred F344,
pubmed-meshheading:21127132-Receptors, Complement,
pubmed-meshheading:21127132-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21127132-Risk Factors,
pubmed-meshheading:21127132-Tissue and Organ Harvesting
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pubmed:year |
2011
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pubmed:articleTitle |
Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation.
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pubmed:affiliation |
Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands. j.damman@chir.umcg.nl
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pubmed:publicationType |
Journal Article
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