Source:http://linkedlifedata.com/resource/pubmed/id/21127031
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2011-2-18
|
| pubmed:abstractText |
Neurotic psychopathology has been extensively examined as a risk factor for nicotine dependence (ND). Genetic stratification may partially explain variability in risk estimates. Genetic variants that compromise dopaminergic neurotransmission may motivate exposure to dopamine-stimulating agents, including nicotine. The 7-repeat allele of a Variable Number Tandem Repeat (VNTR) polymorphism in DRD4 (and evolutionary derivatives 5, 6, and 8 repeats; 7R+) is associated with reduced dopamine receptor function. The purpose of this study was to examine association between both smoking initiation (SI) and progression to ND by young adulthood and (a) history of neuroticism during adolescence, (b) DRD4 7R+, and (c) interaction between neuroticism and DRD4 7R+.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
1469-994X
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
13
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
64-9
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| pubmed:meshHeading |
pubmed-meshheading:21127031-Adolescent,
pubmed-meshheading:21127031-Alleles,
pubmed-meshheading:21127031-Cohort Studies,
pubmed-meshheading:21127031-Exons,
pubmed-meshheading:21127031-Female,
pubmed-meshheading:21127031-Genetic Predisposition to Disease,
pubmed-meshheading:21127031-Genotype,
pubmed-meshheading:21127031-Humans,
pubmed-meshheading:21127031-Longitudinal Studies,
pubmed-meshheading:21127031-Male,
pubmed-meshheading:21127031-Neurotic Disorders,
pubmed-meshheading:21127031-Polymorphism, Genetic,
pubmed-meshheading:21127031-Receptors, Dopamine D4,
pubmed-meshheading:21127031-Smoking,
pubmed-meshheading:21127031-Tandem Repeat Sequences,
pubmed-meshheading:21127031-Tobacco Use Disorder,
pubmed-meshheading:21127031-Victoria,
pubmed-meshheading:21127031-Young Adult
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
A role for the DRD4 exon III VNTR in modifying the association between nicotine dependence and neuroticism.
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| pubmed:affiliation |
Environmental and Genetic Epidemiology Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia. justine.ellis@mcri.edu.au
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|