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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1990-7-19
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pubmed:abstractText |
8-Hydroxydeoxyguanosine (8-OH-dG) levels were examined in liver and kidney DNA after di(2-ethylhexyl)phthalate (DEHP), di(2-ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6-week-old F-344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant increases in 8-OH-dG levels were observed only in the liver (target organ of DEHP and DEHA carcinogenesis) DNA after 1 and 2 weeks of treatment with DEHP and DEHA, respectively. The results suggest the involvement of oxidative DNA damage in hepatocarcinogenesis by peroxisome proliferators.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0910-5050
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-5
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2112523-Adipic Acids,
pubmed-meshheading:2112523-Animals,
pubmed-meshheading:2112523-Carcinogens,
pubmed-meshheading:2112523-DNA,
pubmed-meshheading:2112523-DNA Damage,
pubmed-meshheading:2112523-Deoxyguanosine,
pubmed-meshheading:2112523-Diethylhexyl Phthalate,
pubmed-meshheading:2112523-Liver,
pubmed-meshheading:2112523-Liver Neoplasms, Experimental,
pubmed-meshheading:2112523-Male,
pubmed-meshheading:2112523-Microbodies,
pubmed-meshheading:2112523-Phthalic Acids,
pubmed-meshheading:2112523-Rats,
pubmed-meshheading:2112523-Rats, Inbred F344
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pubmed:year |
1990
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pubmed:articleTitle |
Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate.
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pubmed:affiliation |
Division of Toxicology, National Institute of Hygienic Sciences, Tokyo.
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pubmed:publicationType |
Journal Article
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