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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-12-2
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pubmed:databankReference |
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pubmed:abstractText |
The multiple endocrine neoplasia type I gene functions as a tumor suppressor gene in humans and mouse models. In Drosophila melanogaster, mutants of the menin gene (Mnn1) are hypersensitive to mutagens or gamma irradiation and have profound defects in the response to several stresses including heat shock, hypoxia, hyperosmolarity and oxidative stress. However, it is not known if the function of menin in the stress response contributes to genome stability. The objective of this study was to examine the role of menin in the control of the stress response and genome stability.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e14049
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pubmed:meshHeading |
pubmed-meshheading:21124979-Animals,
pubmed-meshheading:21124979-Anoxia,
pubmed-meshheading:21124979-Cluster Analysis,
pubmed-meshheading:21124979-Drosophila Proteins,
pubmed-meshheading:21124979-Drosophila melanogaster,
pubmed-meshheading:21124979-Gene Deletion,
pubmed-meshheading:21124979-Gene Expression Profiling,
pubmed-meshheading:21124979-Genome, Insect,
pubmed-meshheading:21124979-Genomic Instability,
pubmed-meshheading:21124979-HSP70 Heat-Shock Proteins,
pubmed-meshheading:21124979-Heat-Shock Response,
pubmed-meshheading:21124979-Humans,
pubmed-meshheading:21124979-Loss of Heterozygosity,
pubmed-meshheading:21124979-Mice,
pubmed-meshheading:21124979-Mutation,
pubmed-meshheading:21124979-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21124979-RNA Interference
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pubmed:year |
2010
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pubmed:articleTitle |
Menin links the stress response to genome stability in Drosophila melanogaster.
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pubmed:affiliation |
Department of Biology, McMaster University, Hamilton, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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