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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-12-2
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pubmed:abstractText |
The central nervous system has the capacity to activate profound neuroprotection following sub-lethal stress in a process termed preconditioning. To gain insight into this potent survival response we developed a functional cloning strategy that identified 31 putative neuroprotective genes of which 28 were confirmed to provide protection against oxygen-glucose deprivation (OGD) or excitotoxic exposure to N-methyl-D-aspartate (NMDA) in primary rat cortical neurons. These results reveal that the brain possesses a wide and diverse repertoire of neuroprotective genes. Further characterization of these and other protective signals could provide new treatment opportunities for neurological injury from ischemia or neurodegenerative disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e15008
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pubmed:meshHeading |
pubmed-meshheading:21124846-ADP-Ribosylation Factors,
pubmed-meshheading:21124846-Animals,
pubmed-meshheading:21124846-Blotting, Northern,
pubmed-meshheading:21124846-Calmodulin,
pubmed-meshheading:21124846-Cell Survival,
pubmed-meshheading:21124846-Cells, Cultured,
pubmed-meshheading:21124846-Excitatory Amino Acid Agonists,
pubmed-meshheading:21124846-Fibroblasts,
pubmed-meshheading:21124846-Gene Expression,
pubmed-meshheading:21124846-Glucose,
pubmed-meshheading:21124846-HEK293 Cells,
pubmed-meshheading:21124846-Humans,
pubmed-meshheading:21124846-Immunoblotting,
pubmed-meshheading:21124846-Mice,
pubmed-meshheading:21124846-Mice, Knockout,
pubmed-meshheading:21124846-N-Methylaspartate,
pubmed-meshheading:21124846-Neurons,
pubmed-meshheading:21124846-Oxygen,
pubmed-meshheading:21124846-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:21124846-Proteins,
pubmed-meshheading:21124846-RNA Interference,
pubmed-meshheading:21124846-Rats
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pubmed:year |
2010
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pubmed:articleTitle |
Functional identification of neuroprotective molecules.
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pubmed:affiliation |
Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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