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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-12-21
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pubmed:abstractText |
administration of recombinant human interleukin (IL)-7 leads to CD4 and CD8 T-cell expansions in HIV-infected individuals, demonstrating promising capacity for immune reconstitution. However, a proportion of patients treated with recombinant human IL-7 experience transient increases in plasma HIV-RNA ('blips'), possibly reflecting 'purging' of a quiescent reservoir that provides a barrier to viral eradication.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1473-5571
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pubmed:author |
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pubmed:copyrightInfo |
2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
159-64
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pubmed:meshHeading |
pubmed-meshheading:21124203-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:21124203-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21124203-CD8-Positive T-Lymphocytes,
pubmed-meshheading:21124203-Female,
pubmed-meshheading:21124203-Genes, env,
pubmed-meshheading:21124203-HIV Infections,
pubmed-meshheading:21124203-HIV-1,
pubmed-meshheading:21124203-Humans,
pubmed-meshheading:21124203-Interleukin-7,
pubmed-meshheading:21124203-Lymphocyte Activation,
pubmed-meshheading:21124203-Male,
pubmed-meshheading:21124203-Phylogeny,
pubmed-meshheading:21124203-RNA, Viral,
pubmed-meshheading:21124203-Viral Load,
pubmed-meshheading:21124203-Viremia,
pubmed-meshheading:21124203-Virus Latency
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pubmed:year |
2011
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pubmed:articleTitle |
HIV-1 viruses detected during episodic blips following interleukin-7 administration are similar to the viruses present before and after interleukin-7 therapy.
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pubmed:affiliation |
Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA. himamichi@nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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