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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-3-3
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pubmed:abstractText |
We have previously shown that CLDN4 (encoding claudin-4), a cell tight junction (TJ) protein, is highly expressed in human epithelial ovarian carcinomas (EOC) but undetectable in normal ovaries. CLDN4 has been identified as a specific receptor for C terminus of Clostridium perfringens enterotoxin (C-CPE), a nontoxic molecule that may disrupt TJ barrier function and enhance cellular absorption. The purpose of this study was to determine the potential clinical applications of C-CPE and its effects on CLDN4 expression in EOC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Carboplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligase Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/claudin 4,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin, Clostridium
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:copyrightInfo |
©2010 AACR.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1065-74
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21123456-Animals,
pubmed-meshheading:21123456-Antineoplastic Agents,
pubmed-meshheading:21123456-Blotting, Western,
pubmed-meshheading:21123456-Carboplatin,
pubmed-meshheading:21123456-Cells, Cultured,
pubmed-meshheading:21123456-Clostridium perfringens,
pubmed-meshheading:21123456-Enterotoxins,
pubmed-meshheading:21123456-Epithelial Cells,
pubmed-meshheading:21123456-Female,
pubmed-meshheading:21123456-Fluorescent Antibody Technique,
pubmed-meshheading:21123456-Humans,
pubmed-meshheading:21123456-In Situ Nick-End Labeling,
pubmed-meshheading:21123456-Membrane Proteins,
pubmed-meshheading:21123456-Mice,
pubmed-meshheading:21123456-Mice, SCID,
pubmed-meshheading:21123456-Neoplasms, Glandular and Epithelial,
pubmed-meshheading:21123456-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21123456-Ovarian Neoplasms,
pubmed-meshheading:21123456-Paclitaxel,
pubmed-meshheading:21123456-Polymerase Chain Reaction,
pubmed-meshheading:21123456-Proteasome Endopeptidase Complex,
pubmed-meshheading:21123456-RNA, Messenger,
pubmed-meshheading:21123456-Tight Junctions,
pubmed-meshheading:21123456-Ubiquitin-Protein Ligase Complexes,
pubmed-meshheading:21123456-Xenograft Model Antitumor Assays
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pubmed:year |
2011
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pubmed:articleTitle |
C terminus of Clostridium perfringens enterotoxin downregulates CLDN4 and sensitizes ovarian cancer cells to Taxol and Carboplatin.
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pubmed:affiliation |
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. zhijian_gao@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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