| pubmed-article:21122530 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C0684224 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C0021390 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C0242262 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C0281481 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C1879746 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C1547011 | lld:lifeskim |
| pubmed-article:21122530 | lifeskim:mentions | umls-concept:C1704788 | lld:lifeskim |
| pubmed-article:21122530 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21122530 | pubmed:dateCreated | 2010-12-2 | lld:pubmed |
| pubmed-article:21122530 | pubmed:abstractText | The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways. | lld:pubmed |
| pubmed-article:21122530 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21122530 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122530 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21122530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122530 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21122530 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:21122530 | pubmed:issn | 1876-4479 | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:TeillaudJean-... | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:BaertFilipF | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:LouisEdouardE | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:EliakimRamiR | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:DaneseSilvioS | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:Ben-HorinShom... | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:LémannMarcM | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:AllezMatthieu... | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:VermeireSever... | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:ChowersYehuda... | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:KatsanosKonst... | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:SteinwurzFlav... | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:BrynskovJørnJ | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:KarmirisKonst... | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:KleinAmirA | lld:pubmed |
| pubmed-article:21122530 | pubmed:author | pubmed-author:Van der... | lld:pubmed |
| pubmed-article:21122530 | pubmed:copyrightInfo | Copyright © 2010 European Crohn's and Colitis Organisation. All rights reserved. | lld:pubmed |
| pubmed-article:21122530 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21122530 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:21122530 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21122530 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21122530 | pubmed:pagination | 355-66 | lld:pubmed |
| pubmed-article:21122530 | pubmed:meshHeading | pubmed-meshheading:21122530... | lld:pubmed |
| pubmed-article:21122530 | pubmed:meshHeading | pubmed-meshheading:21122530... | lld:pubmed |
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| pubmed-article:21122530 | pubmed:meshHeading | pubmed-meshheading:21122530... | lld:pubmed |
| pubmed-article:21122530 | pubmed:meshHeading | pubmed-meshheading:21122530... | lld:pubmed |
| pubmed-article:21122530 | pubmed:meshHeading | pubmed-meshheading:21122530... | lld:pubmed |
| pubmed-article:21122530 | pubmed:meshHeading | pubmed-meshheading:21122530... | lld:pubmed |
| pubmed-article:21122530 | pubmed:meshHeading | pubmed-meshheading:21122530... | lld:pubmed |
| pubmed-article:21122530 | pubmed:meshHeading | pubmed-meshheading:21122530... | lld:pubmed |
| pubmed-article:21122530 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21122530 | pubmed:articleTitle | Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects. | lld:pubmed |
| pubmed-article:21122530 | pubmed:affiliation | Department of Gastroenterology, Hôpital Saint-Louis, APHP, Université Paris 7 Denis Diderot, France; Equipe Avenir INSERM U940, France. matthieu.allez@sls.aphp.fr | lld:pubmed |
| pubmed-article:21122530 | pubmed:publicationType | Journal Article | lld:pubmed |
