Source:http://linkedlifedata.com/resource/pubmed/id/21122530
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-12-2
|
| pubmed:abstractText |
The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1876-4479
|
| pubmed:author |
pubmed-author:AllezMatthieuM,
pubmed-author:BaertFilipF,
pubmed-author:Ben-HorinShomronS,
pubmed-author:BrynskovJørnJ,
pubmed-author:ChowersYehudaY,
pubmed-author:DaneseSilvioS,
pubmed-author:EliakimRamiR,
pubmed-author:KarmirisKonstantinosK,
pubmed-author:KatsanosKonstantinosK,
pubmed-author:KleinAmirA,
pubmed-author:LémannMarcM,
pubmed-author:LouisEdouardE,
pubmed-author:SteinwurzFlavioF,
pubmed-author:TeillaudJean-LucJL,
pubmed-author:Van AsscheGertG,
pubmed-author:Van der WoudeJannekeJ,
pubmed-author:VermeireSeverineS
|
| pubmed:copyrightInfo |
Copyright © 2010 European Crohn's and Colitis Organisation. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
355-66
|
| pubmed:meshHeading |
pubmed-meshheading:21122530-Animals,
pubmed-meshheading:21122530-Antibodies, Monoclonal,
pubmed-meshheading:21122530-Colitis, Ulcerative,
pubmed-meshheading:21122530-Crohn Disease,
pubmed-meshheading:21122530-Humans,
pubmed-meshheading:21122530-Inflammatory Bowel Diseases,
pubmed-meshheading:21122530-Mice,
pubmed-meshheading:21122530-Treatment Failure,
pubmed-meshheading:21122530-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects.
|
| pubmed:affiliation |
Department of Gastroenterology, Hôpital Saint-Louis, APHP, Université Paris 7 Denis Diderot, France; Equipe Avenir INSERM U940, France. matthieu.allez@sls.aphp.fr
|
| pubmed:publicationType |
Journal Article
|