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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-7
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pubmed:abstractText |
Bisphosphonates commonly used to treat osteoporosis, Paget's disease, multiple myeloma, hypercalcemia of malignancy and osteolytic lesions of cancer metastasis have been associated with bisphosphonate-associated jaw osteonecrosis (BJON). The underlying pathogenesis of BJON is unclear, but disproportionate bisphosphonate concentration in the jaw has been proposed as one potential etiological factor. This study tested the hypothesis that skeletal biodistribution of intravenous bisphosphonate is anatomic site-dependent in a rat model system.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1601-0825
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 John Wiley & Sons A/S.
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-32
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pubmed:meshHeading |
pubmed-meshheading:21122034-Animals,
pubmed-meshheading:21122034-Bone Density Conservation Agents,
pubmed-meshheading:21122034-Bone and Bones,
pubmed-meshheading:21122034-Calcium,
pubmed-meshheading:21122034-Chelating Agents,
pubmed-meshheading:21122034-Decalcification Technique,
pubmed-meshheading:21122034-Diphosphonates,
pubmed-meshheading:21122034-Durapatite,
pubmed-meshheading:21122034-Edetic Acid,
pubmed-meshheading:21122034-Female,
pubmed-meshheading:21122034-Femur,
pubmed-meshheading:21122034-Fibula,
pubmed-meshheading:21122034-Fluorescent Dyes,
pubmed-meshheading:21122034-Fluorometry,
pubmed-meshheading:21122034-Humerus,
pubmed-meshheading:21122034-Injections, Intravenous,
pubmed-meshheading:21122034-Mandible,
pubmed-meshheading:21122034-Models, Animal,
pubmed-meshheading:21122034-Radius,
pubmed-meshheading:21122034-Rats,
pubmed-meshheading:21122034-Rats, Nude,
pubmed-meshheading:21122034-Spectrophotometry, Atomic,
pubmed-meshheading:21122034-Tibia,
pubmed-meshheading:21122034-Tissue Distribution,
pubmed-meshheading:21122034-Ulna
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pubmed:year |
2011
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pubmed:articleTitle |
Anatomic site variability in rat skeletal uptake and desorption of fluorescently labeled bisphosphonate.
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pubmed:affiliation |
Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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