Linked Life Data

2112063

Source:http://linkedlifedata.com/resource/pubmed/id/2112063

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-7-11
pubmed:abstractText
We compared diagnostic tests for keratoconjunctivitis sicca (KCS) in previously diagnosed patients and normal controls to determine the incidence of true negatives (specificity) and true positives (sensitivity). Tear osmolarity testing, the Schirmer filter paper test, and lactoferrin determination by the Lactoplate radial immunodiffusion (RID) method were performed in 20 KCS patients diagnosed on the basis of presenting symptoms and clinical examination. Similar determinations were performed in 20 age- and sex-matched normal control subjects. Mean lactoferrin concentrations in the right eyes of the KCS patients and normal controls were 134 +/- 78 (+/- 1 SD) mg/dL and 118 +/- 56 mg/dL, respectively. Tear osmolarity was 323 +/- 12 mosm/L and 306 +/- 7 mosm/L, in KCS patients and normal controls, respectively. The Schirmer test yielded a mean of 2.4 +/- 1.8 mm/minute of wetting in the KCS patients and 3.0 +/- 1.4 mm/minute in the controls. Used as a diagnostic test, lactoferrin determination by RID was found to have 35% sensitivity and 70% specificity; tear osmolarity determination had 90% sensitivity and 95% specificity; and the Schirmer test yielded 25% sensitivity and 90% specificity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0733-8902
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-12
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
A comparison of diagnostic tests for keratoconjunctivitis sicca: lactoplate, Schirmer, and tear osmolarity.
pubmed:affiliation
University of Medicine and Dentistry of New Jersey, New Jersey Medical School.
pubmed:publicationType
Journal Article, Comparative Study