Source:http://linkedlifedata.com/resource/pubmed/id/21119108
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2011-2-4
|
| pubmed:abstractText |
We describe outcomes after human leukocyte antigen-matched sibling bone marrow transplantation (BMT) for 179 patients with ?-thalassemia major. The median age at transplantation was 7 years and the median follow-up was 6 years. The distribution of Pesaro risk class I, II, and III categories was 2%, 42%, and 36%, respectively. The day 30 cumulative incidence of neutrophil recovery and day 100 platelet recovery were 90% and 86%, respectively. Seventeen patients had graft failure, which was fatal in 11. Six of 9 patients with graft failure are alive after a second transplantation. The day 100 probability of acute graft-versus-host disease and 5-year probability of chronic graft-versus-host disease was 38% and 13%, respectively. The 5-year probabilities of overall- and disease-free survival were 91% and 88%, respectively, for patients with Pesaro risk class II, and 64% and 62%, respectively, for Pesaro risk class III. In multivariate analysis, mortality risks were higher in patients 7 years of age and older and those with hepatomegaly before BMT. The leading causes of death were interstitial pneumonitis (n = 7), hemorrhage (n = 8), and veno-occlusive disease (n = 6). Proceeding to BMT in children younger than 7 years before development of end-organ damage, particularly in the liver, should improve results after BMT for ?-thalassemia major.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1528-0020
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| pubmed:author |
pubmed-author:BredesonChristopher NCN,
pubmed-author:ChandyMammenM,
pubmed-author:CowanMorton JMJ,
pubmed-author:EapenMaryM,
pubmed-author:GaleRobert PeterRP,
pubmed-author:GhavamzadehArdeshirA,
pubmed-author:HaleGregory AGA,
pubmed-author:HongengSuradejS,
pubmed-author:HoranJohnJ,
pubmed-author:IrfanSyed MohammadSM,
pubmed-author:LiChi-KongCK,
pubmed-author:LoganBrent RBR,
pubmed-author:SabloffMitchellM,
pubmed-author:WaltersMark CMC,
pubmed-author:WangZhiweiZ
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
3
|
| pubmed:volume |
117
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1745-50
|
| pubmed:meshHeading |
pubmed-meshheading:21119108-Adolescent,
pubmed-meshheading:21119108-Adult,
pubmed-meshheading:21119108-Bone Marrow Transplantation,
pubmed-meshheading:21119108-Child,
pubmed-meshheading:21119108-Child, Preschool,
pubmed-meshheading:21119108-Female,
pubmed-meshheading:21119108-Graft Rejection,
pubmed-meshheading:21119108-Graft Survival,
pubmed-meshheading:21119108-Graft vs Host Disease,
pubmed-meshheading:21119108-HLA Antigens,
pubmed-meshheading:21119108-Humans,
pubmed-meshheading:21119108-International Agencies,
pubmed-meshheading:21119108-Male,
pubmed-meshheading:21119108-Siblings,
pubmed-meshheading:21119108-Survival Rate,
pubmed-meshheading:21119108-Tissue Donors,
pubmed-meshheading:21119108-Transplantation, Homologous,
pubmed-meshheading:21119108-Treatment Outcome,
pubmed-meshheading:21119108-Young Adult,
pubmed-meshheading:21119108-beta-Thalassemia
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
HLA-matched sibling bone marrow transplantation for ?-thalassemia major.
|
| pubmed:affiliation |
Ottawa Hospital Blood & Marrow Transplant Program, Ottawa, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
|