Linked Life Data

21118967

Source:http://linkedlifedata.com/resource/pubmed/id/21118967

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2010-12-8
pubmed:abstractText
MicroRNAs (miRNA) play important roles in tumorigenesis. Genetic variations in miRNA processing genes and miRNA binding sites may affect the biogenesis of miRNA and the regulatory effect of miRNAs to their target genes, hence promoting tumorigenesis. This study analyzed 226 single nucleotide polymorphisms (SNP) in miRNA processing genes and miRNA binding sites in 339 ovarian cancer cases and 349 healthy controls to assess association with cancer risk, overall survival, and treatment response. Thirteen polymorphisms were found to have significant association with risk. The most significant were 2 linked SNPs (r(2) = 0.99), rs2740351 and rs7813 in GEMIN4 [odds ratio (OR) = 0.71; 95% confidence interval (CI), 0.57-0.87 and OR = 0.71; 95% CI, 0.57-0.88, respectively]. Unfavorable genotype analysis showed the cumulative effect of these 13 SNPs on risk (P for trend < 0.0001). Potential higher order gene-gene interactions were identified, which categorized patients into different risk groups according to their genotypic signatures. In the clinical outcome study, 24 SNPs exhibited significant association with overall survival and 17 SNPs with treatment response. Notably, patients carrying a rare homozygous genotype of rs1425486 in PDGFC had poorer overall survival [hazard ratio (HR) = 2.69; 95% CI, 1.67-4.33] and worse treatment response (OR = 3.38; 95% CI, 1.39-8.19), compared to carriers of common homozygous and heterozygous genotypes. Unfavorable genotype analyses also showed a strong gene-dosage effect with decreased survival and increased risk of treatment nonresponse in patients with greater number of unfavorable genotypes (P for trend < 0.0001). Taken together, miRNA-related genetic polymorphisms may impact ovarian cancer predisposition and clinical outcome both individually and jointly.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1538-7445
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9765-76
pubmed:meshHeading
pubmed-meshheading:21118967-Adult, pubmed-meshheading:21118967-Aged, pubmed-meshheading:21118967-Aged, 80 and over, pubmed-meshheading:21118967-Binding Sites, pubmed-meshheading:21118967-Biosynthetic Pathways, pubmed-meshheading:21118967-Cell Line, Tumor, pubmed-meshheading:21118967-Female, pubmed-meshheading:21118967-Genetic Predisposition to Disease, pubmed-meshheading:21118967-Genotype, pubmed-meshheading:21118967-Haplotypes, pubmed-meshheading:21118967-Humans, pubmed-meshheading:21118967-Kaplan-Meier Estimate, pubmed-meshheading:21118967-Lymphokines, pubmed-meshheading:21118967-MicroRNAs, pubmed-meshheading:21118967-Middle Aged, pubmed-meshheading:21118967-Odds Ratio, pubmed-meshheading:21118967-Ovarian Neoplasms, pubmed-meshheading:21118967-Platelet-Derived Growth Factor, pubmed-meshheading:21118967-Polymorphism, Single Nucleotide, pubmed-meshheading:21118967-Ribonucleoproteins, Small Nuclear, pubmed-meshheading:21118967-Risk Assessment, pubmed-meshheading:21118967-Risk Factors, pubmed-meshheading:21118967-Transfection, pubmed-meshheading:21118967-Treatment Outcome
pubmed:year
2010
pubmed:articleTitle
Genetic variants in MicroRNA biosynthesis pathways and binding sites modify ovarian cancer risk, survival, and treatment response.
pubmed:affiliation
College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.