| pubmed-article:21118710 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21118710 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:21118710 | lifeskim:mentions | umls-concept:C0030193 | lld:lifeskim |
| pubmed-article:21118710 | lifeskim:mentions | umls-concept:C0031117 | lld:lifeskim |
| pubmed-article:21118710 | lifeskim:mentions | umls-concept:C0017070 | lld:lifeskim |
| pubmed-article:21118710 | lifeskim:mentions | umls-concept:C0332221 | lld:lifeskim |
| pubmed-article:21118710 | pubmed:dateCreated | 2011-1-12 | lld:pubmed |
| pubmed-article:21118710 | pubmed:abstractText | Paclitaxel is one of the most commonly used anti-neoplastic drugs for the treatment of solid tumors. Unfortunately, its use is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. However, there are few clinically available drugs or drug classes for the treatment of paclitaxel-induced neuropathy due to a lack of information regarding the mechanisms responsible for it. In this study, we examined the involvement of l-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV). We used a preclinical rat model of paclitaxel-induced painful peripheral neuropathy. Response to von Frey filaments, SNCV, 3-phosphoglycerate dehydrogenase (3PGDH) expression, and l-serine concentration were examined. Effects of l-serine administration were also investigated. Paclitaxel treatment induced mechanical allodynia/hyperalgesia and reduction of SNCV. Paclitaxel also decreased the l-serine concentration in the dorsal root ganglion (DRG) but not in the sciatic nerve or spinal cord. In addition, paclitaxel decreased expression of 3PGDH, a biosynthetic enzyme of l-serine, in the DRG. Immunohistochemistry showed that 3PGDH was localized in satellite cells but not in neurons in the DRG. Intraperitoneal administration of l-serine improved both paclitaxel-induced mechanical allodynia/hyperalgesia and the reduction of SNCV. These results suggest that satellite cell-derived l-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy. | lld:pubmed |
| pubmed-article:21118710 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21118710 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21118710 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21118710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21118710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21118710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21118710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21118710 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21118710 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21118710 | pubmed:issn | 1873-7544 | lld:pubmed |
| pubmed-article:21118710 | pubmed:author | pubmed-author:NamikiAA | lld:pubmed |
| pubmed-article:21118710 | pubmed:author | pubmed-author:KawamataTT | lld:pubmed |
| pubmed-article:21118710 | pubmed:author | pubmed-author:KiyaTT | lld:pubmed |
| pubmed-article:21118710 | pubmed:author | pubmed-author:YamakageMM | lld:pubmed |
| pubmed-article:21118710 | pubmed:copyrightInfo | Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21118710 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21118710 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:21118710 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:21118710 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21118710 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21118710 | pubmed:pagination | 190-9 | lld:pubmed |
| pubmed-article:21118710 | pubmed:meshHeading | pubmed-meshheading:21118710... | lld:pubmed |
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| pubmed-article:21118710 | pubmed:meshHeading | pubmed-meshheading:21118710... | lld:pubmed |
| pubmed-article:21118710 | pubmed:meshHeading | pubmed-meshheading:21118710... | lld:pubmed |
| pubmed-article:21118710 | pubmed:meshHeading | pubmed-meshheading:21118710... | lld:pubmed |
| pubmed-article:21118710 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21118710 | pubmed:articleTitle | Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy. | lld:pubmed |
| pubmed-article:21118710 | pubmed:affiliation | Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. | lld:pubmed |
| pubmed-article:21118710 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21118710 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
