Source:http://linkedlifedata.com/resource/pubmed/id/21118710
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2011-1-12
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| pubmed:abstractText |
Paclitaxel is one of the most commonly used anti-neoplastic drugs for the treatment of solid tumors. Unfortunately, its use is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. However, there are few clinically available drugs or drug classes for the treatment of paclitaxel-induced neuropathy due to a lack of information regarding the mechanisms responsible for it. In this study, we examined the involvement of l-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV). We used a preclinical rat model of paclitaxel-induced painful peripheral neuropathy. Response to von Frey filaments, SNCV, 3-phosphoglycerate dehydrogenase (3PGDH) expression, and l-serine concentration were examined. Effects of l-serine administration were also investigated. Paclitaxel treatment induced mechanical allodynia/hyperalgesia and reduction of SNCV. Paclitaxel also decreased the l-serine concentration in the dorsal root ganglion (DRG) but not in the sciatic nerve or spinal cord. In addition, paclitaxel decreased expression of 3PGDH, a biosynthetic enzyme of l-serine, in the DRG. Immunohistochemistry showed that 3PGDH was localized in satellite cells but not in neurons in the DRG. Intraperitoneal administration of l-serine improved both paclitaxel-induced mechanical allodynia/hyperalgesia and the reduction of SNCV. These results suggest that satellite cell-derived l-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1873-7544
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
3
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| pubmed:volume |
174
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
190-9
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| pubmed:meshHeading |
pubmed-meshheading:21118710-Animals,
pubmed-meshheading:21118710-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:21118710-Cold Temperature,
pubmed-meshheading:21118710-Ganglia, Spinal,
pubmed-meshheading:21118710-Hyperalgesia,
pubmed-meshheading:21118710-Male,
pubmed-meshheading:21118710-Neural Conduction,
pubmed-meshheading:21118710-Paclitaxel,
pubmed-meshheading:21118710-Pain,
pubmed-meshheading:21118710-Peripheral Nervous System Diseases,
pubmed-meshheading:21118710-Phosphoglycerate Dehydrogenase,
pubmed-meshheading:21118710-Rats,
pubmed-meshheading:21118710-Rats, Sprague-Dawley,
pubmed-meshheading:21118710-Satellite Cells, Perineuronal,
pubmed-meshheading:21118710-Serine,
pubmed-meshheading:21118710-Stereoisomerism,
pubmed-meshheading:21118710-Tail,
pubmed-meshheading:21118710-Touch
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| pubmed:year |
2011
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| pubmed:articleTitle |
Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy.
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| pubmed:affiliation |
Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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