|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2011-4-18
|
|
pubmed:abstractText |
It is well known that the innate immune system can induce and regulate the development of adaptive immunity. The NLRP3 inflammasome is a multiprotein complex that controls the caspase-1 activation step that is a pre-requisite for the maturation of interleukin (IL)-1? and IL-18. Recent findings showed that the NLRP3 inflammasome not only is an innate responder to pathogenic and danger signals, but also can affect the adaptive immune response. Here we review the role of NLRP3 inflammasome in regulating adaptive immunity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1878-1705
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright © 2010 Elsevier B.V. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
549-54
|
|
pubmed:meshHeading |
pubmed-meshheading:21118671-Adaptive Immunity,
pubmed-meshheading:21118671-Adjuvants, Immunologic,
pubmed-meshheading:21118671-Animals,
pubmed-meshheading:21118671-Carrier Proteins,
pubmed-meshheading:21118671-Cell Communication,
pubmed-meshheading:21118671-Humans,
pubmed-meshheading:21118671-Immunity, Innate,
pubmed-meshheading:21118671-Inflammasomes,
pubmed-meshheading:21118671-Multiprotein Complexes,
pubmed-meshheading:21118671-Th1-Th2 Balance
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Regulation of adaptive immunity by the NLRP3 inflammasome.
|
|
pubmed:affiliation |
Unit of Innate Immunity, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
|
|
pubmed:publicationType |
Journal Article,
Review
|
