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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-6-29
pubmed:abstractText
We have investigated the effects of interleukin 1 (IL-1) administration on the ability of neutropenic mice to resist Pseudomonas aeruginosa challenge in vivo. Cyclophosphamide-treated mice received human rIL-1 beta at 7.0, 0.7, or 00.7 micrograms/kg, according to different regimens, to be challenged with a lethal ip inoculum of pseudomonas cells 5 days after myelosuppression. The repeated exposure of the neutropenic mice to an overall cytokine dosage of 7.0 or 0.7 micrograms/kg during the 4 days after myelosuppression was found to optimally restore the animals' antibacterial resistance. However, when administered as a single injection 24 hr before challenge, the same dosages of IL-1 had lower or no effect in enhancing survival, primarily leading only to a reduction in the amount of antipseudomonal chemotherapy required for cure. The regimen of IL-1 administration conferring optimal protection also resulted in a decrease in the number of pseudomonas cells recovered from the peritoneal cavity of infected mice. This regimen accelerated hematopoietic recovery in cyclophosphamide-treated mice. Assay of serum colony-stimulating activity (CSA) revealed that (a) cyclophosphamide treatment alone significantly increased the level of circulating CSA, (b) administration of a single dose of IL-1 to neutropenic mice induced an early, further increase in serum CSA, followed by depression, (c) a biphasic pattern of CSA response was also evident in mice repeatedly treated with IL-1. These results suggest that regulation of hematopoiesis may have an important role in the induction of antibacterial resistance in myelosuppressed hosts repeatedly treated with low dosages of IL-1.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
250-60
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed-meshheading:2111738-Animals, pubmed-meshheading:2111738-Blood Bactericidal Activity, pubmed-meshheading:2111738-Colony-Forming Units Assay, pubmed-meshheading:2111738-Cyclophosphamide, pubmed-meshheading:2111738-Dose-Response Relationship, Drug, pubmed-meshheading:2111738-Female, pubmed-meshheading:2111738-Gentamicins, pubmed-meshheading:2111738-Hematopoiesis, pubmed-meshheading:2111738-Immunotherapy, pubmed-meshheading:2111738-Interleukin-1, pubmed-meshheading:2111738-Leukocyte Count, pubmed-meshheading:2111738-Mice, pubmed-meshheading:2111738-Mice, Inbred BALB C, pubmed-meshheading:2111738-Neutrophils, pubmed-meshheading:2111738-Pseudomonas Infections, pubmed-meshheading:2111738-Pseudomonas aeruginosa, pubmed-meshheading:2111738-Recombinant Proteins, pubmed-meshheading:2111738-Time Factors
pubmed:year
1990
pubmed:articleTitle
Antibacterial resistance induced by recombinant interleukin 1 in myelosuppressed mice: effect of treatment schedule and correlation with colony-stimulating activity in the bloodstream.
pubmed:affiliation
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
pubmed:publicationType
Journal Article