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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-7
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pubmed:abstractText |
Gene expression regulation in Leishmania has been related to post-transcriptional events involving mainly sequences present in the 5' and 3' untranslated regions. PABPs are high-affinity poly(A)-binding proteins that are implicated in the regulation of translation initiation, RNA stability and other important biological processes. We describe a PABP from Leishmania infantum (LiPABP) that shows a very high homology with PABPs from other eukaryotic organisms, including mammals and other parasites. LiPABP conserves the main domains present in other PABPs, maintains poly(A)-binding properties and is phosphorylated by p38 mitogen-activated protein kinase. Using the sera from dogs infected with L. infantum, we demonstrate that LiPABP is expressed in L. infantum promastigotes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1873-3468
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
585
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-8
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pubmed:meshHeading |
pubmed-meshheading:21115009-Amino Acid Sequence,
pubmed-meshheading:21115009-Animals,
pubmed-meshheading:21115009-Blotting, Western,
pubmed-meshheading:21115009-Cloning, Molecular,
pubmed-meshheading:21115009-Cluster Analysis,
pubmed-meshheading:21115009-Dogs,
pubmed-meshheading:21115009-HEK293 Cells,
pubmed-meshheading:21115009-Humans,
pubmed-meshheading:21115009-Immune Sera,
pubmed-meshheading:21115009-Leishmania infantum,
pubmed-meshheading:21115009-Molecular Sequence Data,
pubmed-meshheading:21115009-Phosphorylation,
pubmed-meshheading:21115009-Phylogeny,
pubmed-meshheading:21115009-Poly(A)-Binding Proteins,
pubmed-meshheading:21115009-Poly A,
pubmed-meshheading:21115009-Protozoan Proteins,
pubmed-meshheading:21115009-Sequence Homology, Amino Acid,
pubmed-meshheading:21115009-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2011
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pubmed:articleTitle |
Identification and functional characterization of a poly(A)-binding protein from Leishmania infantum (LiPABP).
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pubmed:affiliation |
Servicio de Bioquímica-Investigación, Hospital Ramón y Cajal, IRyCIS, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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