Linked Life Data

21114974

Source:http://linkedlifedata.com/resource/pubmed/id/21114974

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2010-12-27
pubmed:abstractText
Statins have pleiotropic vascular protective effects that are independent of their cholesterol-lowering effects. The aim of the present study was to determine if statins have anti-flushing actions in an animal model of forced exercise-induced temperature dysregulation in menopausal hot flushes, and to clarify the critical role of statins in regulating vascular reactivity in the tail arteries of ovariectomized rats. Administration of fluvastatin or pravastatin (3mg/kg/day for 7days, p.o.) significantly ameliorated the flushing of tail skin in ovariectomized mice, and the effect of each statin was comparable with that of estrogen replacement (1mg/kg/week for 3weeks, i.m.). In phenylephrine-pre-contracted rat-tail arteries, ovariectomy inhibited acetylcholine-induced relaxation, but augmented sodium nitroprusside-induced relaxation. These ovariectomy-altered vasodilator responses were restored by fluvastatin treatment as well as by estrogen replacement. Nitrite/nitrate levels in the plasma of ovariectomized animals showed significantly lower values than those in sham-operated animals; this ovariectomy-reduced production of nitric oxide was improved by fluvastatin treatment. These data provide the first experimental evidence that statins such as fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals. Thus, therapeutic methods that target improvement of vasomotor dysfunction could be novel strategies for reducing menopausal hot flushes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1879-0712
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
651
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
234-9
pubmed:meshHeading
pubmed-meshheading:21114974-Animals, pubmed-meshheading:21114974-Arteries, pubmed-meshheading:21114974-Body Weight, pubmed-meshheading:21114974-Estrogen Replacement Therapy, pubmed-meshheading:21114974-Fatty Acids, Monounsaturated, pubmed-meshheading:21114974-Female, pubmed-meshheading:21114974-Hot Flashes, pubmed-meshheading:21114974-Indoles, pubmed-meshheading:21114974-Menopause, pubmed-meshheading:21114974-Mice, pubmed-meshheading:21114974-Nitric Oxide, pubmed-meshheading:21114974-Organ Size, pubmed-meshheading:21114974-Ovariectomy, pubmed-meshheading:21114974-Physical Conditioning, Animal, pubmed-meshheading:21114974-Pravastatin, pubmed-meshheading:21114974-Rats, pubmed-meshheading:21114974-Skin, pubmed-meshheading:21114974-Uterus, pubmed-meshheading:21114974-Vasoconstriction, pubmed-meshheading:21114974-Vasodilation, pubmed-meshheading:21114974-Vasomotor System
pubmed:year
2011
pubmed:articleTitle
The statins fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals.
pubmed:affiliation
Department of Pharmaceutical Care and Health Sciences, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan. shuto@fukuoka-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't