Source:http://linkedlifedata.com/resource/pubmed/id/21114483
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-12-23
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| pubmed:abstractText |
Modern intensive chemotherapy for childhood haematological malignancies has led to high cure rates, but has detrimental effects on the immune system. There is little knowledge concerning long-term recovery of the adaptive immune system. Here we studied the long-term reconstitution of the adaptive immune system in 31 children treated for haematological malignancies between July 2000 and October 2006. We performed detailed phenotypical and functional analyses of the various B and T cell subpopulations until 5 years after chemotherapy. We show that recovery of newly-developed transitional B cells and naive B and T cells occurred rapidly, within months, whereas recovery of the different memory B and T cell subpopulations was slower and incomplete, even after 5 years post-chemotherapy. The speed of B and T cell recovery was age-independent, despite a significant contribution of the thymus to T cell recovery. Plasmablast B cell levels remained above normal and immunoglobulin levels normalised within 1 week. Functional T cell responses were normal, even within the first year post-chemotherapy. This study shows that after intensive chemotherapy for haematological malignancies in children, numbers of several memory B and T cell subpopulations were decreased on the long term, while functional T cell responses were not compromised.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1365-2141
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| pubmed:author |
pubmed-author:BieringsMarc BMB,
pubmed-author:BloemAndries CAC,
pubmed-author:BorghansJosé A MJA,
pubmed-author:GaiserJacobus FJF,
pubmed-author:Janssens-KorpelaPirkko LPL,
pubmed-author:NibbelkeElisabeth EEE,
pubmed-author:OttoSigrid ASA,
pubmed-author:SandersElisabeth A MEA,
pubmed-author:TesselaarKikiK,
pubmed-author:WolfsTom F WTF,
pubmed-author:van GentRogierR,
pubmed-author:van TilburgCornelis MCM
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| pubmed:copyrightInfo |
© 2010 Blackwell Publishing Ltd.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
152
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
201-10
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| pubmed:meshHeading |
pubmed-meshheading:21114483-Adaptive Immunity,
pubmed-meshheading:21114483-Adolescent,
pubmed-meshheading:21114483-Age Factors,
pubmed-meshheading:21114483-Antineoplastic Agents,
pubmed-meshheading:21114483-B-Lymphocyte Subsets,
pubmed-meshheading:21114483-Cell Proliferation,
pubmed-meshheading:21114483-Child,
pubmed-meshheading:21114483-Child, Preschool,
pubmed-meshheading:21114483-Female,
pubmed-meshheading:21114483-Follow-Up Studies,
pubmed-meshheading:21114483-Hematologic Neoplasms,
pubmed-meshheading:21114483-Humans,
pubmed-meshheading:21114483-Immunoglobulins,
pubmed-meshheading:21114483-Immunophenotyping,
pubmed-meshheading:21114483-Lymphocyte Activation,
pubmed-meshheading:21114483-Lymphocyte Count,
pubmed-meshheading:21114483-Male,
pubmed-meshheading:21114483-T-Lymphocyte Subsets,
pubmed-meshheading:21114483-Thymus Gland
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Immune reconstitution in children following chemotherapy for haematological malignancies: a long-term follow-up.
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| pubmed:affiliation |
Department of Paediatric Haematology/Oncology, University Medical Center Utrecht, The Netherlands. c.m.vantilburg@umcutrecht.nl
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|