Linked Life Data

21113841

Source:http://linkedlifedata.com/resource/pubmed/id/21113841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-11-29
pubmed:abstractText
Renal damage of diabetic patients is linked to chronic low-grade inflammation. The aim of this study was to analyze urinary concentrations of 27 cytokines in type 2 diabetic patients with normo- and microalbuminuria by multiplex bead immunoassay. Urinary levels of IL-8, IP-10, MCP-1, G-CSF, EOTAXIN, RANTES, and TNF-? in microalbuminuric patients were significantly increased compared to those in normoalbuminuric patients (p < 0.05) or controls (p < 0.05). GM-CSF, MIP-1?, and MIP-1? levels were more elevated in microalbuminuric patients than in controls (both p < 0.05). IP-10 and MCP-1 levels were correlated with urinary albumin excretion rate (r = 0.668 and 0.544, both p < 0.01), and estimated glomerular filtration rate (r = -0.454 and -0.418, both p < 0.05). EOTAXIN, GM-CSF, IP-10, MCP-1, and RANTES levels were correlated with HbA1c (r = 0.457, 0.466, 0.678, 0.567, 0.542, respectively, p ? 0.01). These results indicate that urinary cytokine determination might be useful for the early diagnosis and management of patients with diabetic nephropathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1532-4230
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-89
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Multiplex bead analysis of urinary cytokines of type 2 diabetic patients with normo- and microalbuminuria.
pubmed:affiliation
Department of Endocrinology, First Hospital Affiliated, Medical School of Xi'an Jiaotong University, Shaanxi, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't