Linked Life Data

21112485

Source:http://linkedlifedata.com/resource/pubmed/id/21112485

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-11-29
pubmed:abstractText
Oxidative stress plays an important role in retinal pigmental epithelium (RPE) death during aging and the development of age-related macular degeneration. Although early reports indicate that reactive oxygen species (ROS) including H?O? can trigger apoptosis at lower concentrations and necrosis at higher concentrations, the exact molecular mechanism of RPE death is still unclear. The purpose of this study was to investigate the molecular pathways involved in RPE death induced by exogenous ROS, especially at higher concentrations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0895-3988
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 The Editorial Board of Biomedical and Environmental Sciences. Published by Elsevier B.V. All rights reserved.
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
371-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Calcium overload is a critical step in programmed necrosis of ARPE-19 cells induced by high-concentration H?O?.
pubmed:affiliation
Department of Ophthalmology, Second Hospital of Jilin University, Changchun 130041, Jilin, China. liguangyu_box@yahoo.com.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't