Linked Life Data

21111716

Source:http://linkedlifedata.com/resource/pubmed/id/21111716

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-1-17
pubmed:abstractText
This study examined the neuroprotective effects of magnesium-sulfate (MgSO(4)) on the cerebral blood flow (CBF) and extracellular glutamate concentration in an eleven vessel occlusion (11VO) rat model. Twenty-one male Sprague-Dawley rats (250-350g) were used for the 11VO ischemic model, which was induced by a 10-min transient occlusion. The animals were divided into 3 groups, including ischemic-induced animals (ischemia group), ischemic-induced and MgSO(4) treated animals (MgSO(4) group), and sham animals for comparison. The real-time extracellular glutamate concentration was measured using a microdialysis biosensor, and the CBF was monitored by laser Doppler flowmetry. Neuronal cell death in the hippocampal region was observed 72h after ischemia by several stains (Nissl, DAPI, NeuN, and cleaved caspase3). A significant decrease in %CBF was observed in both the ischemia and MgSO(4) groups, such as ~10% during the ischemic period. However, the MgSO(4) group showed a significant decrease in the initial reperfusion %CBF compared to the ischemia group. A significantly lower level of glutamate release was observed in the MgSO(4) group than in the ischemia group during the ischemic and reperfusion episode. Our staining results revealed a significant decrease in neuronal cell death in the hippocampus in the MgSO(4) group compared to the ischemia group. These results suggest that MgSO(4) is responsible for the protection of neuronal cells by suppressing the release of extracellular glutamate under ischemic conditions and the CBF response during the initial reperfusion period.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1872-6240
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
31
pubmed:volume
1371
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-8
pubmed:meshHeading
pubmed-meshheading:21111716-Animals, pubmed-meshheading:21111716-Antigens, Nuclear, pubmed-meshheading:21111716-Apoptosis, pubmed-meshheading:21111716-Brain Ischemia, pubmed-meshheading:21111716-CA1 Region, Hippocampal, pubmed-meshheading:21111716-Caspase 3, pubmed-meshheading:21111716-Cerebrovascular Circulation, pubmed-meshheading:21111716-Drug Evaluation, Preclinical, pubmed-meshheading:21111716-Glutamic Acid, pubmed-meshheading:21111716-Laser-Doppler Flowmetry, pubmed-meshheading:21111716-Magnesium Sulfate, pubmed-meshheading:21111716-Male, pubmed-meshheading:21111716-Nerve Tissue Proteins, pubmed-meshheading:21111716-Neuroprotective Agents, pubmed-meshheading:21111716-Neurotoxins, pubmed-meshheading:21111716-Pyramidal Cells, pubmed-meshheading:21111716-Rats, pubmed-meshheading:21111716-Rats, Sprague-Dawley, pubmed-meshheading:21111716-Reperfusion Injury, pubmed-meshheading:21111716-Single-Blind Method
pubmed:year
2011
pubmed:articleTitle
Neuroprotective effects of magnesium-sulfate on ischemic injury mediated by modulating the release of glutamate and reduced of hyperreperfusion.
pubmed:affiliation
Department of Biomedical Engineering and Healthcare Industry Research Institute, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't