Source:http://linkedlifedata.com/resource/pubmed/id/21111401
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2011-6-15
|
| pubmed:abstractText |
New efforts to develop treatments for cognitive dysfunction in mental illnesses would benefit enormously from biomarkers that provide sensitive and reliable measures of the neural events underlying cognition. Here, we evaluate the promise of event-related potentials (ERPs) as biomarkers of cognitive dysfunction in schizophrenia. We conclude that ERPs have several desirable properties: (1) they provide a direct measure of electrical activity during neurotransmission; (2) their high temporal resolutions make it possible to measure neural synchrony and oscillations; (3) they are relatively inexpensive and convenient to record; (4) animal models are readily available for several ERP components; (5) decades of research has established the sensitivity and reliability of ERP measures in psychiatric illnesses; and 6) feasibility of large N (>500) multisite studies has been demonstrated for key measures. Consequently, ERPs may be useful for identifying endophenotypes and defining treatment targets, for evaluating new compounds in animals and in humans, and for identifying individuals who are good candidates for early interventions or for specific treatments. However, several challenges must be overcome before ERPs gain widespread use as biomarkers in schizophrenia research, and we make several recommendations for the research that is necessary to develop and validate ERP-based biomarkers that can have a real impact on treatment development.
|
| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/P41-RR14075,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB006385-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH062150-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH076226-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH076226-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH076989-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH080187-04,
http://linkedlifedata.com/resource/pubmed/grant/R01EB006385,
http://linkedlifedata.com/resource/pubmed/grant/R01EB009048,
http://linkedlifedata.com/resource/pubmed/grant/R01MH065034,
http://linkedlifedata.com/resource/pubmed/grant/R01MH076226,
http://linkedlifedata.com/resource/pubmed/grant/R01MH076989,
http://linkedlifedata.com/resource/pubmed/grant/R01MH080187,
http://linkedlifedata.com/resource/pubmed/grant/R01MH082022,
http://linkedlifedata.com/resource/pubmed/grant/R01MH62150,
http://linkedlifedata.com/resource/pubmed/grant/R21 MH091774-01,
http://linkedlifedata.com/resource/pubmed/grant/R21 MH091774-02,
http://linkedlifedata.com/resource/pubmed/grant/R37 MH049334-20,
http://linkedlifedata.com/resource/pubmed/grant/R37MH49334,
http://linkedlifedata.com/resource/pubmed/grant/RR025761,
http://linkedlifedata.com/resource/pubmed/grant/UL1 RR025761-02
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1873-2402
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
28-34
|
| pubmed:meshHeading |
pubmed-meshheading:21111401-Animals,
pubmed-meshheading:21111401-Biological Markers,
pubmed-meshheading:21111401-Brain Mapping,
pubmed-meshheading:21111401-Evoked Potentials,
pubmed-meshheading:21111401-Humans,
pubmed-meshheading:21111401-Reproducibility of Results,
pubmed-meshheading:21111401-Schizophrenia
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
A roadmap for the development and validation of event-related potential biomarkers in schizophrenia research.
|
| pubmed:affiliation |
Center for Mind & Brain and Department of Psychology, University of California, Davis, Davis, California 95618, USA. sjluck@ucdavis.edu
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|