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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-12-14
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pubmed:abstractText |
In the recessive aminoaciduria Lysinuric Protein Intolerance (LPI), mutations of SLC7A7/y+LAT1 impair system y+L transport activity for cationic amino acids. A severe complication of LPI is a form of Pulmonary Alveolar Proteinosis (PAP), in which alveolar spaces are filled with lipoproteinaceous material because of the impaired surfactant clearance by resident macrophages. The pathogenesis of LPI-associated PAP remains still obscure. The present study investigates for the first time the expression and function of y+LAT1 in monocytes and macrophages isolated from a patient affected by LPI-associated PAP. A comparison with mesenchymal cells from the same subject has been also performed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-10080183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-11078698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-11239408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-11377971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-1155480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-11950832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-12805087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-12810105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-12871728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-12896880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-14695413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-14770310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-15280038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-15289783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-15294901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-15746185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-15776427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-15877200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-16056256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-16880524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-17363779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-17386098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-17397797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-1779632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-17848583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-19380772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-19562367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-19796925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-19824815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-20030831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-7356668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-7844671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-8192561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-8319714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-8404187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-8564125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-9829974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21110863-9931537
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1750-1172
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pubmed:author |
pubmed-author:BarilliAmeliaA,
pubmed-author:BussolatiOvidioO,
pubmed-author:Dall'AstaValeriaV,
pubmed-author:GazzolaGian CGC,
pubmed-author:KadijaZamirZ,
pubmed-author:LuisettiMaurizioM,
pubmed-author:MarianiFrancescaF,
pubmed-author:RodiGiuseppeG,
pubmed-author:RotoliBianca MariaBM,
pubmed-author:RuzzaMaria LorenaML,
pubmed-author:VisigalliRossanaR
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
32
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:21110863-Adult,
pubmed-meshheading:21110863-Amino Acid Metabolism, Inborn Errors,
pubmed-meshheading:21110863-Antigens, CD98 Light Chains,
pubmed-meshheading:21110863-Cell Differentiation,
pubmed-meshheading:21110863-Cells, Cultured,
pubmed-meshheading:21110863-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:21110863-Humans,
pubmed-meshheading:21110863-Lysine,
pubmed-meshheading:21110863-Macrophages, Alveolar,
pubmed-meshheading:21110863-Male,
pubmed-meshheading:21110863-Monocytes,
pubmed-meshheading:21110863-Pulmonary Alveolar Proteinosis,
pubmed-meshheading:21110863-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
In Lysinuric Protein Intolerance system y+L activity is defective in monocytes and in GM-CSF-differentiated macrophages.
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pubmed:affiliation |
Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Università degli Studi di Parma, Parma, Italy.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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