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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-12-14
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pubmed:abstractText |
Marek's disease virus (MDV) is an oncogenic herpesvirus, which causes malignant lymphoma in chickens. The Meq protein of MDV, which is expressed abundantly in MDV-infected cells and in Marek's disease (MD) tumor cells, functions as a transcriptional activator and has been proposed to play an important role in oncogenic transformation. Preliminary studies demonstrated that Meq is able to bind p53 in vitro, as demonstrated using a protein-binding assay. This observation prompted us to examine whether the interaction between Meq and p53 occurs in cells, and to investigate the biological significance of this interaction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1743-422X
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pubmed:author |
pubmed-author:ChenHongjunH,
pubmed-author:ChenPuyanP,
pubmed-author:DengXufangX,
pubmed-author:DingChanC,
pubmed-author:JinYameiY,
pubmed-author:LiXiangdongX,
pubmed-author:MaZhiyongZ,
pubmed-author:QiuYafengY,
pubmed-author:ShaoDonghuaD,
pubmed-author:ShenYangY,
pubmed-author:ShiZixueZ,
pubmed-author:XXX
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
348
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pubmed:meshHeading |
pubmed-meshheading:21110861-Animals,
pubmed-meshheading:21110861-Apoptosis,
pubmed-meshheading:21110861-Binding Sites,
pubmed-meshheading:21110861-Cells, Cultured,
pubmed-meshheading:21110861-Chickens,
pubmed-meshheading:21110861-Gene Deletion,
pubmed-meshheading:21110861-Genes, Reporter,
pubmed-meshheading:21110861-Humans,
pubmed-meshheading:21110861-Immunoprecipitation,
pubmed-meshheading:21110861-In Situ Nick-End Labeling,
pubmed-meshheading:21110861-Luciferases,
pubmed-meshheading:21110861-Mardivirus,
pubmed-meshheading:21110861-Oncogene Proteins,
pubmed-meshheading:21110861-Protein Binding,
pubmed-meshheading:21110861-Protein Interaction Mapping,
pubmed-meshheading:21110861-Sequence Deletion,
pubmed-meshheading:21110861-Transcription, Genetic,
pubmed-meshheading:21110861-Tumor Suppressor Protein p53,
pubmed-meshheading:21110861-Two-Hybrid System Techniques,
pubmed-meshheading:21110861-Viral Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities.
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pubmed:affiliation |
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai 200241, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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