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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-12-15
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pubmed:abstractText |
A severe encephalitis that associates with auto-antibodies to the NR1 subunit of the NMDA receptor (NMDA-R) was recently reported. Patients' antibodies cause a decrease of the density of NMDA-R and synaptic mediated currents, but the in vivo effects on the extracellular glutamate and glutamatergic transmission are unknown.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1750-1172
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31
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pubmed:meshHeading |
pubmed-meshheading:21110857-Animals,
pubmed-meshheading:21110857-Autoantibodies,
pubmed-meshheading:21110857-Autoimmune Diseases of the Nervous System,
pubmed-meshheading:21110857-Encephalitis,
pubmed-meshheading:21110857-Glutamates,
pubmed-meshheading:21110857-Humans,
pubmed-meshheading:21110857-Immunoglobulin G,
pubmed-meshheading:21110857-Male,
pubmed-meshheading:21110857-Rats,
pubmed-meshheading:21110857-Rats, Wistar,
pubmed-meshheading:21110857-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:21110857-Synaptic Transmission
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pubmed:year |
2010
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pubmed:articleTitle |
In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction.
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pubmed:affiliation |
FNRS-Laboratoire de Neurologie Expérimentale, ULB, Belgium. mmanto@ulb.ac.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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