Source:http://linkedlifedata.com/resource/pubmed/id/21109952
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2010-11-26
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| pubmed:abstractText |
Salivary gland tumours (SGT) constitute a diagnostically challenging group of neoplasms with frequently unpredictable clinical outcome. The proliferation rate facilitates the identification of aggressive SGT. The Chromatin Assembly Factor-1 (CAF-1) is a major epigenetic regulator of nuclear chromatin organization during DNA replication. It plays a critical function in human tumourigenesis and has been proposed as a new proliferation and prognostic marker for some malignancies. This study focused on the role of CAF-1/p60 protein as a marker of clinical value for SGT. The expression of CAF-1/p60 was evaluated by immunohistochemistry on a retrospective series of 362 surgically excised benign and malignant SGT with different histogenesis and, when available, on fine-needle pre-surgical cytological biopsies. The resulting data were compared with traditional prognostic parameters, including the expression of the routine proliferation marker ki67/MIB1. CAF-1/p60 was detectable in all SGT, with highest degree of expression in metastasizing malignant tumours. Moreover, the cases of benign tumours which progressed to carcinoma during the follow-up, showed significantly higher CAF-1/p60 expression than non-progressing benign SGT, both on histological sections and cytological smears of the primary tumour. Cox's multiple regression analysis selected CAF-1/p60 expression as the best independent predictor of cancer development for benign SGT (p<0.0001), and the best independent predictor of metastasis onset for malignant tumours (p<0.0004). Overexpression of CAF-1/p60, on histological and/or cytological samples, characterizes malignant SGT with aggressive behaviour, irrespective of their specific histotype, and allows the early diagnosis of progression toward malignancy of morphologically benign tumours.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1791-2431
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| pubmed:author |
pubmed-author:BufoPantaleoP,
pubmed-author:CalifanoLuigiL,
pubmed-author:De RosaGaetanoG,
pubmed-author:IlardiGennaroG,
pubmed-author:Lo MuzioLorenzoL,
pubmed-author:MascoloMassimoM,
pubmed-author:NugnesLoredanaL,
pubmed-author:PannoneGiuseppeG,
pubmed-author:RoccoAlbaA,
pubmed-author:SianoMariaM,
pubmed-author:StaibanoStefaniaS,
pubmed-author:VecchioneMaria LuisaML,
pubmed-author:ZampareseRosannaR
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| pubmed:issnType |
Electronic
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
13-22
|
| pubmed:meshHeading |
pubmed-meshheading:21109952-Adolescent,
pubmed-meshheading:21109952-Adult,
pubmed-meshheading:21109952-Aged,
pubmed-meshheading:21109952-Aged, 80 and over,
pubmed-meshheading:21109952-Cell Proliferation,
pubmed-meshheading:21109952-Child,
pubmed-meshheading:21109952-Chromatin Assembly Factor-1,
pubmed-meshheading:21109952-Female,
pubmed-meshheading:21109952-Humans,
pubmed-meshheading:21109952-Immunohistochemistry,
pubmed-meshheading:21109952-Male,
pubmed-meshheading:21109952-Middle Aged,
pubmed-meshheading:21109952-Prognosis,
pubmed-meshheading:21109952-Proportional Hazards Models,
pubmed-meshheading:21109952-ROC Curve,
pubmed-meshheading:21109952-Salivary Gland Neoplasms,
pubmed-meshheading:21109952-Sensitivity and Specificity,
pubmed-meshheading:21109952-Tumor Markers, Biological
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| pubmed:year |
2011
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| pubmed:articleTitle |
The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours.
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| pubmed:affiliation |
Department of Biomorphological and Functional Sciences, Pathology Section, School of Medicine, University Federico II of Naples, Naples, Italy. staibano@unina.it
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|