Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6008
pubmed:dateCreated
2010-11-26
pubmed:databankReference
pubmed:abstractText
Kaposi's sarcoma-associated herpesvirus produces a highly abundant, nuclear noncoding RNA, polyadenylated nuclear (PAN) RNA, which contains an element that prevents its decay. The 79-nucleotide expression and nuclear retention element (ENE) was proposed to adopt a secondary structure like that of a box H/ACA small nucleolar RNA (snoRNA), with a U-rich internal loop that hybridizes to and protects the PAN RNA poly(A) tail. The crystal structure of a complex between the 40-nucleotide ENE core and oligo(A)(9) RNA at 2.5 angstrom resolution reveals that unlike snoRNAs, the U-rich loop of the ENE engages its target through formation of a major-groove triple helix. A-minor interactions extend the binding interface. Deadenylation assays confirm the functional importance of the triple helix. Thus, the ENE acts as an intramolecular RNA clamp, sequestering the PAN poly(A) tail and preventing the initiation of RNA decay.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-11238840, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-11276255, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-11296253, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-11345429, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-13499402, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-1418737, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-14749774, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-15157733, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-15749017, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-15861127, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-16091217, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-17189195, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-17412831, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-17466623, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-17563387, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-18204466, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-18334997, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-18598933, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-18950640, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-20227365, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-20865011, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-6828386, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-8692871, http://linkedlifedata.com/resource/pubmed/commentcorrection/21109672-8876232
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
26
pubmed:volume
330
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1244-7
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Poly(A) tail recognition by a viral RNA element through assembly of a triple helix.
pubmed:affiliation
Department of Molecular Biophysics and Biochemistry (MB&B), Howard Hughes Medical Institute (HHMI), Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536-9812, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural