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pubmed:abstractText |
A series of novel hydroxamic acid based histone deacetylases (HDAC) inhibitors with aryl ether and aryl sulfone residues at the terminus of a substituted, unsaturated 5-carbon spacer moiety have been synthesized for the first time and evaluated. Compounds with meta- and para-substitution on the aryl ring of ether hydroxamic acids 19c, 20c, 19e, 19f and 19g are potent HDAC inhibitors with activities at low nanomolar levels.
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pubmed:affiliation |
AMRI, Medicinal Chemistry Department, 30 Corporate Circle, PO Box 15098, Albany, NY 12212, USA. brian.gregg@amriglobal.com
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