Source:http://linkedlifedata.com/resource/pubmed/id/21108969
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-1-10
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| pubmed:abstractText |
To investigate the anti-herpesvirus mechanism of pentagalloylglucose (PGG), we compared the proteomic changes between herpes simplex virus type 1 (HSV-1) infected MRC-5 cells with or without PGG-treatment, and between non-infected MRC-5 cells with or without PGG-treatment by 2-DE and MS-based analysis. Differentially expressed cellular proteins were mainly involved with actin cytoskeleton regulation. Significantly, PGG can down-regulate cofilin1, a key regulator of actin cytoskeleton dynamics. PGG can inhibit HSV-1-induced rearrangements of actin cytoskeleton which is important for infectivity. Furthermore, cofilin1 knockdown by siRNA also inhibited the HSV-1-induced actin-skeleton rearrangements. Both PGG-treatment and cofilin1 knockdown can reduce HSV-1 DNA, mRNA, protein synthesis and virus yields. Altogether, the results suggested that down-regulating cofilin1 plays a role in PGG inhibiting HSV-1 infection. PGG may be a promising anti-herpesvirus agent for drug development.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
|
| pubmed:issn |
1872-9096
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| pubmed:author |
pubmed-author:ChenJia-NanJN,
pubmed-author:ChuI SIS,
pubmed-author:HaoJingJ,
pubmed-author:JuHuai-QiangHQ,
pubmed-author:KitazatoKaioK,
pubmed-author:LaiChi-choiCC,
pubmed-author:LiuQiu-YingQY,
pubmed-author:LuChun-HuaCH,
pubmed-author:PeiYingY,
pubmed-author:QianChui-WenCW,
pubmed-author:QuChangC,
pubmed-author:QuM MMM,
pubmed-author:RIADNN,
pubmed-author:ShenLiL,
pubmed-author:WangYi-FeiYF,
pubmed-author:XiangYang-FeiYF,
pubmed-author:XiongShengS,
pubmed-author:YangChong-RenCR,
pubmed-author:ZengFan-LiFL,
pubmed-author:ZhangPei-ZhuoPZ,
pubmed-author:ZhangYing-JunYJ
|
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier B.V. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
89
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
98-108
|
| pubmed:meshHeading |
pubmed-meshheading:21108969-Animals,
pubmed-meshheading:21108969-Cell Line,
pubmed-meshheading:21108969-Cercopithecus aethiops,
pubmed-meshheading:21108969-Cofilin 1,
pubmed-meshheading:21108969-Down-Regulation,
pubmed-meshheading:21108969-Gene Knockdown Techniques,
pubmed-meshheading:21108969-Herpesvirus 1, Human,
pubmed-meshheading:21108969-Humans,
pubmed-meshheading:21108969-Hydrolyzable Tannins,
pubmed-meshheading:21108969-RNA, Small Interfering,
pubmed-meshheading:21108969-Virus Internalization
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection.
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| pubmed:affiliation |
Biomedicine Research and Development Center of Jinan University, Guangzhou Huangpu Road West 601, Guangzhou, Guangdong 510632, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|