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pubmed-article:21108812pubmed:abstractTextThe DLX gene family encodes for homeobox transcription factors involved in the control of morphogenesis and tissue homeostasis. Their expression can be regulated by Endothelin1 (ET1), a peptide associated with breast cancer invasive phenotype. Deregulation of DLX gene expression was found in human solid tumors and hematologic malignancies. In particular, DLX4 overexpression represents a possible prognostic marker in ovarian cancer. We have investigated the role of DLX genes in human breast cancer progression.lld:pubmed
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pubmed-article:21108812pubmed:articleTitleMutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231.lld:pubmed
pubmed-article:21108812pubmed:affiliationDepartment of Experimental Medicine, University of Genova, Largo R, Benzi 10, 16132 Genova, Italy.lld:pubmed
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