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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0035647,
umls-concept:C0036525,
umls-concept:C0185117,
umls-concept:C0332281,
umls-concept:C1414076,
umls-concept:C1414079,
umls-concept:C1512505,
umls-concept:C1522484,
umls-concept:C1548966,
umls-concept:C2911684
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pubmed:dateCreated |
2010-12-20
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pubmed:abstractText |
The DLX gene family encodes for homeobox transcription factors involved in the control of morphogenesis and tissue homeostasis. Their expression can be regulated by Endothelin1 (ET1), a peptide associated with breast cancer invasive phenotype. Deregulation of DLX gene expression was found in human solid tumors and hematologic malignancies. In particular, DLX4 overexpression represents a possible prognostic marker in ovarian cancer. We have investigated the role of DLX genes in human breast cancer progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649
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pubmed:meshHeading |
pubmed-meshheading:21108812-Animals,
pubmed-meshheading:21108812-Bone Neoplasms,
pubmed-meshheading:21108812-Breast Neoplasms,
pubmed-meshheading:21108812-Cell Line, Tumor,
pubmed-meshheading:21108812-Cell Movement,
pubmed-meshheading:21108812-Disease-Free Survival,
pubmed-meshheading:21108812-Endothelin-1,
pubmed-meshheading:21108812-Female,
pubmed-meshheading:21108812-Gene Expression Profiling,
pubmed-meshheading:21108812-Homeodomain Proteins,
pubmed-meshheading:21108812-Humans,
pubmed-meshheading:21108812-In Situ Hybridization,
pubmed-meshheading:21108812-Kaplan-Meier Estimate,
pubmed-meshheading:21108812-Lung Neoplasms,
pubmed-meshheading:21108812-Mice,
pubmed-meshheading:21108812-Mice, Nude,
pubmed-meshheading:21108812-Neoplasm Invasiveness,
pubmed-meshheading:21108812-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21108812-Prognosis,
pubmed-meshheading:21108812-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21108812-Time Factors,
pubmed-meshheading:21108812-Transcription Factors,
pubmed-meshheading:21108812-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231.
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pubmed:affiliation |
Department of Experimental Medicine, University of Genova, Largo R, Benzi 10, 16132 Genova, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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