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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-1-21
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pubmed:abstractText |
Resolving the nonicosahedral components in large icosahedral viruses remains a technical challenge in structural virology. We have used the emerging technique of Zernike phase-contrast electron cryomicroscopy to enhance the image contrast of ice-embedded herpes simplex virus type 1 capsids. Image reconstruction enabled us to retrieve the structure of the unique portal vertex in the context of the icosahedral capsid and, for the first time, show the subunit organization of a portal in a virus infecting eukaryotes. Our map unequivocally resolves the 12-subunit portal situated beneath one of the pentameric vertices, thus removing uncertainty over the location and stoichiometry of the herpesvirus portal.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-11545320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-11602732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-15071181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-15507654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-16211007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-16452981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-16730179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-16859925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-17053784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-17151101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-17188319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-17215290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-17698370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-18082423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-18971278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-19157711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-20543830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-20696391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21106752-9654678
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1098-5514
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1871-4
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
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pubmed:year |
2011
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pubmed:articleTitle |
Seeing the portal in herpes simplex virus type 1 B capsids.
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pubmed:affiliation |
Structural Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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