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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6271
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pubmed:dateCreated |
1990-6-8
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pubmed:abstractText |
Triggering of contraction in striated muscles involves a conformational transition in the N-terminal domain of troponin C, the calcium-binding component of thin filaments. We have designed a mutant troponin C in which the key conformational transition and the calcium-regulatory activity are reversibly blocked by the formation of a disulphide bridge. Our results may be applicable to other proteins of the same family of calcium-binding proteins.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aziridines,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Dansyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Disulfides,
http://linkedlifedata.com/resource/pubmed/chemical/Dithiothreitol,
http://linkedlifedata.com/resource/pubmed/chemical/Edetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Troponin,
http://linkedlifedata.com/resource/pubmed/chemical/Troponin C,
http://linkedlifedata.com/resource/pubmed/chemical/Troponin I,
http://linkedlifedata.com/resource/pubmed/chemical/Troponin T,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/dansylaziridine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
345
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
132-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2110625-Animals,
pubmed-meshheading:2110625-Aziridines,
pubmed-meshheading:2110625-Binding Sites,
pubmed-meshheading:2110625-Calcium,
pubmed-meshheading:2110625-Crystallization,
pubmed-meshheading:2110625-Dansyl Compounds,
pubmed-meshheading:2110625-Disulfides,
pubmed-meshheading:2110625-Dithiothreitol,
pubmed-meshheading:2110625-Edetic Acid,
pubmed-meshheading:2110625-Fluorescent Dyes,
pubmed-meshheading:2110625-Muscle Contraction,
pubmed-meshheading:2110625-Mutation,
pubmed-meshheading:2110625-Protein Conformation,
pubmed-meshheading:2110625-Rabbits,
pubmed-meshheading:2110625-Spectrometry, Fluorescence,
pubmed-meshheading:2110625-Structure-Activity Relationship,
pubmed-meshheading:2110625-Troponin,
pubmed-meshheading:2110625-Troponin C,
pubmed-meshheading:2110625-Troponin I,
pubmed-meshheading:2110625-Troponin T,
pubmed-meshheading:2110625-Tyrosine
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pubmed:year |
1990
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pubmed:articleTitle |
Inhibition of mutant troponin C activity by an intra-domain disulphide bond.
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pubmed:affiliation |
Department of Muscle Research, Boston Biomedical Research Institute, Massachusetts 02114.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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