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pubmed:abstractText |
The distribution of two-point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional ?(2) approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two-point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution ½?²?+ ½?²?, which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies.
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pubmed:affiliation |
Department of Clinical Sciences, McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. chao.xing@utsouthestern.edu
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