Source:http://linkedlifedata.com/resource/pubmed/id/21104785
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2010-12-14
|
pubmed:abstractText |
The heparin-degrading endosulfatases sulfatase 1 (SULF1) and sulfatase 2 (SULF2) have opposing effects in hepatocarcinogenesis despite structural similarity. Using mRNA expression arrays, we analyzed the correlations of SULF expression with signaling networks in human hepatocellular carcinomas (HCCs) and the associations of SULF expression with tumor phenotype and patient survival. Data from two mRNA microarray analyses of 139 and 36 HCCs and adjacent tissues were used as training and validation sets. Partek and Metacore software were used to identify SULF correlated genes and their associated signaling pathways. Associations between SULF expression, the hepatoblast subtype of HCC, and survival were examined. Both SULF1 and 2 had strong positive correlations with periostin, IQGAP1, TGFB1, and vimentin and inverse correlations with HNF4A and IQGAP2. Genes correlated with both SULFs were highly associated with the cell adhesion, cytoskeletal remodeling, blood coagulation, TGFB, and Wnt/?-catenin and epithelial mesenchymal transition signaling pathways. Genes uniquely correlated with SULF2 were more associated with neoplastic processes than genes uniquely correlated with SULF1. High SULF expression was associated with the hepatoblast subtype of HCC. There was a bimodal effect of SULF1 expression on prognosis, with patients in the lowest or highest tertile having a worse prognosis than those in the middle tertile. SULFs have complex effects on HCC signaling and patient survival. There are functionally similar associations with cell adhesion, ECM remodeling, TGFB, and WNT pathways, but also unique associations of SULF1 and SULF2. The roles and targeting of the SULFs in cancer require further investigation.
|
pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/CA100882,
http://linkedlifedata.com/resource/pubmed/grant/CA128633,
http://linkedlifedata.com/resource/pubmed/grant/P30 CA015083-32,
http://linkedlifedata.com/resource/pubmed/grant/P30 DK084567-01,
http://linkedlifedata.com/resource/pubmed/grant/P30DK084567,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA100882-04,
http://linkedlifedata.com/resource/pubmed/grant/R21 CA128633-01A2,
http://linkedlifedata.com/resource/pubmed/grant/R56 CA100882-06A1
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1098-2264
|
pubmed:author |
pubmed-author:ChuIn-SunIS,
pubmed-author:DoveRebeccaR,
pubmed-author:HuChunlingC,
pubmed-author:KangKoo JeongKJ,
pubmed-author:LaiJinpingJ,
pubmed-author:LeeJu-SeogJS,
pubmed-author:NakamuraIkuoI,
pubmed-author:RobertsLewis RLR,
pubmed-author:SunZhifuZ,
pubmed-author:ThorgeirssonSnorri SSS,
pubmed-author:YangJu DongJD
|
pubmed:copyrightInfo |
© 2010 Wiley-Liss, Inc.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
50
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
122-35
|
pubmed:dateRevised |
2011-10-31
|
pubmed:meshHeading |
pubmed-meshheading:21104785-Carcinoma, Hepatocellular,
pubmed-meshheading:21104785-Databases, Genetic,
pubmed-meshheading:21104785-Female,
pubmed-meshheading:21104785-Gene Expression Profiling,
pubmed-meshheading:21104785-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21104785-Genetic Association Studies,
pubmed-meshheading:21104785-Humans,
pubmed-meshheading:21104785-Liver Neoplasms,
pubmed-meshheading:21104785-Male,
pubmed-meshheading:21104785-Microarray Analysis,
pubmed-meshheading:21104785-Phenotype,
pubmed-meshheading:21104785-RNA, Messenger,
pubmed-meshheading:21104785-Reproducibility of Results,
pubmed-meshheading:21104785-Signal Transduction,
pubmed-meshheading:21104785-Sulfotransferases,
pubmed-meshheading:21104785-Survival Analysis
|
pubmed:year |
2011
|
pubmed:articleTitle |
Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival.
|
pubmed:affiliation |
Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|