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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-7
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pubmed:abstractText |
Several studies have provided compelling evidence implicating the Notch signalling pathway in diabetic nephropathy. Co-regulation of Notch signalling pathway genes with GREM1 has recently been demonstrated and several genes involved in the Notch pathway are differentially expressed in kidney biopsies from individuals with diabetic nephropathy. We assessed single-nucleotide polymorphisms (SNPs; n = 42) in four of these key genes (JAG1, HES1, NOTCH3 and ADAM10) for association with diabetic nephropathy using a case-control design.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADAM Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ADAM10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HES1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NOTCH3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Serrate proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1432-0428
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
334-8
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pubmed:meshHeading |
pubmed-meshheading:21103979-ADAM Proteins,
pubmed-meshheading:21103979-Adolescent,
pubmed-meshheading:21103979-Adult,
pubmed-meshheading:21103979-Amyloid Precursor Protein Secretases,
pubmed-meshheading:21103979-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:21103979-Calcium-Binding Proteins,
pubmed-meshheading:21103979-Child,
pubmed-meshheading:21103979-Diabetes Mellitus, Type 1,
pubmed-meshheading:21103979-Diabetic Nephropathies,
pubmed-meshheading:21103979-Epithelial-Mesenchymal Transition,
pubmed-meshheading:21103979-Female,
pubmed-meshheading:21103979-Genetic Predisposition to Disease,
pubmed-meshheading:21103979-Genotype,
pubmed-meshheading:21103979-Homeodomain Proteins,
pubmed-meshheading:21103979-Humans,
pubmed-meshheading:21103979-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:21103979-Male,
pubmed-meshheading:21103979-Membrane Proteins,
pubmed-meshheading:21103979-Polymorphism, Single Nucleotide,
pubmed-meshheading:21103979-Receptors, Notch,
pubmed-meshheading:21103979-Signal Transduction,
pubmed-meshheading:21103979-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Association analysis of Notch pathway signalling genes in diabetic nephropathy.
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pubmed:affiliation |
Nephrology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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