Linked Life Data

21103944

Source:http://linkedlifedata.com/resource/pubmed/id/21103944

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pubmed-article:21103944pubmed:abstractTextRap1 is rapidly activated upon chemoattractant stimulation and plays an important role in cell adhesion and cytoskeletal reorganization during chemotaxis. Here, we demonstrate that G-protein coupled receptors and G-proteins are essential for chemoattractant-mediated Rap1 activation in Dictyostelium. The rapid Rap1 activation upon cAMP chemoattractant stimulation was absent in cells lacking chemoattractant cAMP receptors cAR1/cAR3 or a subunit of the heterotrimeric G-protein complex G?2. Loss of guanylyl cyclases GCA/SGC or a cGMP-binding protein GbpC exhibited no effect on Rap1 activation kinetics. These results suggest that Rap1, a key regulator for the regulation of cytoskeletal reorganization during cell movement, is activated through the G-protein coupled receptors cAR1/cAR3 and G?2 proteins in a way independent of the cGMP signaling pathway.lld:pubmed
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pubmed-article:21103944pubmed:authorpubmed-author:LeeSung HSHlld:pubmed
pubmed-article:21103944pubmed:authorpubmed-author:JeonTaeck JTJlld:pubmed
pubmed-article:21103944pubmed:authorpubmed-author:ChaInjunIlld:pubmed
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pubmed-article:21103944pubmed:volume30lld:pubmed
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pubmed-article:21103944pubmed:articleTitleChemoattractant-mediated Rap1 activation requires GPCR/G proteins.lld:pubmed
pubmed-article:21103944pubmed:affiliationDepartment of Biology, College of Natural Sciences, Chosun University, Gwangju 501-759, Korea.lld:pubmed
pubmed-article:21103944pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21103944pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed