Linked Life Data

21103366

Source:http://linkedlifedata.com/resource/pubmed/id/21103366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-11-24
pubmed:abstractText
The liver X receptors (LXRs) are a family of nuclear receptor transcription factors that are activated by oxysterols and have defined roles in both lipid metabolism and cholesterol regulation. LXRs also affect antimicrobial responses and have anti-inflammatory effects in macrophages. As mice lacking LXRs are more susceptible to infection by intracellular bacteria Listeria monocytogenes and Mycobacterium tuberculosis, we hypothesized that LXR might also influence macrophage responses to the intracellular protozoan parasite Leishmania chagasi/infantum, a causative agent of visceral leishmaniasis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1935-2735
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e886
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
LXR deficiency confers increased protection against visceral Leishmania infection in mice.
pubmed:affiliation
Department of Medicine, Division of Dermatology and Infectious Diseases, Harbor-University of California Los Angeles Medical Center and Los Angeles Biomedical Research Institute, Torrance, California, USA. kbruhn@labiomed.org
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't