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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-24
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pubmed:abstractText |
The pathogenesis of Alzheimer's disease is attributed to misfolding of Amyloid-? (A?) peptides. A? is generated during amyloidogenic processing of A?-precursor protein (APP). Another characteristic of the AD brain is increased phosphorylation of APP amino acid Tyr(682). Tyr(682) is part of the Y(682)ENPTY(687) motif, a docking site for interaction with cytosolic proteins that regulate APP metabolism and signaling. For example, normal A? generation and secretion are dependent upon Tyr(682) in vitro. However, physiological functions of Tyr(682) are unknown.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e15503
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pubmed:meshHeading |
pubmed-meshheading:21103325-Amyloid,
pubmed-meshheading:21103325-Amyloid beta-Peptides,
pubmed-meshheading:21103325-Amyloid beta-Protein Precursor,
pubmed-meshheading:21103325-Animals,
pubmed-meshheading:21103325-Binding Sites,
pubmed-meshheading:21103325-Brain,
pubmed-meshheading:21103325-Cells, Cultured,
pubmed-meshheading:21103325-Gene Knock-In Techniques,
pubmed-meshheading:21103325-Immunoblotting,
pubmed-meshheading:21103325-Mice,
pubmed-meshheading:21103325-Mice, Inbred C57BL,
pubmed-meshheading:21103325-Mutation,
pubmed-meshheading:21103325-Neurons,
pubmed-meshheading:21103325-Peptide Fragments,
pubmed-meshheading:21103325-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21103325-Synaptosomes,
pubmed-meshheading:21103325-Tyrosine
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pubmed:year |
2010
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pubmed:articleTitle |
Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.
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pubmed:affiliation |
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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